ACTA2 and CFL1

Data Source:
HPRD (in vitro)

		ACTA2	CFL1
Description		actin alpha 2, smooth muscle	cofilin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Cytosol Dynactin Complex Lamellipodium Filopodium Smooth Muscle Contractile Fiber Protein-containing Complex Cell Body Extracellular Exosome	Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome
	Molecular Function	ATP Binding Protein Kinase Binding	Protein Binding Actin Filament Binding
	Biological Process	Muscle Contraction Regulation Of Blood Pressure Response To Virus Positive Regulation Of Gene Expression Vascular Associated Smooth Muscle Contraction Positive Regulation Of Transcription, DNA-templated Glomerular Mesangial Cell Development Mesenchyme Migration	Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Viral Process Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Interleukin-12-mediated Signaling Pathway Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Cell Motility Actin Filament Severing Establishment Of Spindle Localization Regulation Of Dendritic Spine Morphogenesis
Pathways		Smooth Muscle Contraction NOTCH4 Intracellular Domain Regulates Transcription	Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Phenethyl Isothiocyanate	Dodecyldimethylamine N-oxide Copper Artenimol
Diseases		Familial thoracic aortic aneurysm and dissection (TAAD); Aortic aneurysm familial thoracic type (AAT)
GWAS		Arthritis (juvenile idiopathic) ( 33106285) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic lymphocytic leukemia ( 26956414 23770605) Immunoglobulin A ( 20694011) Lymphocyte percentage of white cells ( 32888494) Pulse pressure ( 30578418) Selective IgA deficiency ( 27723758)	Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) White blood cell count ( 32888494)
Interacting Genes		18 interacting genes: CCT4 CCT5 CFL1 CREBBP DNASE1 EP300 GC MINK1 MYL1 MYOC PCYT1B PRKCD SELE SHBG SNTA1 TMSB4X UBE3A YBX1	43 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ERBB2 ERBB3 ERBB4 ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ
Entrez ID		59	1072
HPRD ID		00031	03261
Ensembl ID		ENSG00000107796	ENSG00000172757
Uniprot IDs		D2JYH4 P62736	P23528 V9HWI5
PDB IDs			1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO
Enriched GO Terms of Interacting Partners?
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