ERCC4 and SLX4

Data Source:
HPRD (in vivo, two hybrid)

		ERCC4	SLX4
Description		ERCC excision repair 4, endonuclease catalytic subunit	SLX4 structure-specific endonuclease subunit
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GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 1 Complex Chromosome, Telomeric Region Nucleus Nucleoplasm ERCC4-ERCC1 Complex	Chromosome, Telomeric Region Chromatin Nucleoplasm Cytosol Cell Junction Slx1-Slx4 Complex Holliday Junction Resolvase Complex ERCC4-ERCC1 Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity TFIID-class Transcription Factor Complex Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding Telomerase Inhibitor Activity Identical Protein Binding Protein N-terminus Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity Promoter-specific Chromatin Binding	DNA Binding Protein Binding Enzyme Activator Activity Crossover Junction Endodeoxyribonuclease Activity 5'-flap Endonuclease Activity Enzyme Binding Metal Ion Binding 3'-flap Endonuclease Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Double-strand Break Repair Via Nonhomologous End Joining Response To UV UV Protection Regulation Of Autophagy Negative Regulation Of Telomere Maintenance Nucleotide-excision Repair, DNA Incision Cellular Response To UV Interstrand Cross-link Repair Negative Regulation Of Telomerase Activity Telomeric DNA-containing Double Minutes Formation Global Genome Nucleotide-excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Protection From Non-homologous End Joining At Telomere Negative Regulation Of Double-stranded Telomeric DNA Binding	Meiotic DNA Double-strand Break Processing Resolution Of Meiotic Recombination Intermediates Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Nucleotide-excision Repair DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Interstrand Cross-link Repair Regulation Of Catalytic Activity Telomeric D-loop Disassembly Response To Intra-S DNA Damage Checkpoint Signaling T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of T-circle Formation
Pathways		HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Bilirubin levels ( 22085899) Bipolar disorder lithium response (categorical) or schizophrenia ( 29121268) Bitter alcoholic beverage consumption ( 31046077) Bone mineral density (total hip) ( 29883787) Conduct disorder (symptom count) ( 20585324) Egg allergy ( 25710614) Emphysema imaging phenotypes ( 26030696) Metabolic syndrome ( 20694148) Night sleep phenotypes ( 27126917) Number of sexual partners ( 30643258) Risk-taking tendency (4-domain principal component model) ( 30643258) Schizophrenia ( 28991256 25056061 29483656 30285260) Smoking status (ever vs never smokers) ( 30643258) Triglyceride levels ( 31170924)	Type 2 diabetes ( 32499647)
Interacting Genes		13 interacting genes: ERCC1 FANCG GTF2H1 KIF11 RAD52 RPA1 RPA2 SLX1A SLX4 SPTAN1 SUMO2 TACC1 XPA	8 interacting genes: APP EME1 ERCC4 MUS81 PLK3 SLX1A UBC UBE2I
Entrez ID		2072	84464
HPRD ID		00594	12537
Ensembl ID		ENSG00000175595	ENSG00000188827
Uniprot IDs		A0A1W1GSK9 B4DXD8 Q92889	Q8IY92
PDB IDs		1Z00 2A1J 2AQ0 2KN7 2MUT 6SXA 6SXB	4M7C 4UYI 4ZOU
Enriched GO Terms of Interacting Partners?
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