PTPRZ1 and ARHGAP35

Data Source:
HPRD (in vitro)

		PTPRZ1	ARHGAP35
Description		protein tyrosine phosphatase receptor type Z1	Rho GTPase activating protein 35
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Plasma Membrane	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Ciliary Basal Body
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding	DNA Binding GTPase Activity GTPase Activator Activity GTP Binding Phospholipid Binding
	Biological Process	Protein Dephosphorylation Central Nervous System Development Learning Or Memory Cytokine-mediated Signaling Pathway Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation	Neural Tube Closure Signal Transduction Axon Guidance Axonal Fasciculation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Central Nervous System Neuron Axonogenesis Mammary Gland Development Forebrain Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cellular Response To Extracellular Stimulus Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rho Protein Signal Transduction Camera-type Eye Development Negative Regulation Of Vascular Permeability Positive Regulation Of GTPase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Cilium Assembly Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Guidance
Pathways		Other interleukin signaling	Rho GTPase cycle Sema4D mediated inhibition of cell attachment and migration PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases
GWAS		Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)	Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579)
Interacting Genes		13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR	6 interacting genes: CDC42 GRB2 KRT31 PTPRZ1 RAC1 SRC
Entrez ID		5803	2909
HPRD ID		01481	05592
Ensembl ID		ENSG00000106278	ENSG00000160007
Uniprot IDs		B4DFE7 P23471	Q9NRY4
PDB IDs		3JXF 3S97 5AWX 5H08	2K85 3C5H 3FK2 6PXC 6WAY
Enriched GO Terms of Interacting Partners?
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