ARHGAP35 and PTPRZ1

Data Source:
HPRD (in vitro)

		ARHGAP35	PTPRZ1
Description		Rho GTPase activating protein 35	protein tyrosine phosphatase receptor type Z1
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GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Actin Cytoskeleton Ciliary Basal Body	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	DNA Binding GTPase Activity GTPase Activator Activity GTP Binding Phospholipid Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding
	Biological Process	Neural Tube Closure Signal Transduction Axon Guidance Axonal Fasciculation Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cell Shape Positive Regulation Of Neuron Projection Development Cell Migration Central Nervous System Neuron Axonogenesis Mammary Gland Development Forebrain Development Establishment Or Maintenance Of Actin Cytoskeleton Polarity Cellular Response To Extracellular Stimulus Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Rho Protein Signal Transduction Camera-type Eye Development Negative Regulation Of Vascular Permeability Positive Regulation Of GTPase Activity Wound Healing, Spreading Of Cells Positive Regulation Of Cilium Assembly Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Neuron Projection Guidance	Protein Dephosphorylation Central Nervous System Development Learning Or Memory Cytokine-mediated Signaling Pathway Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Rho GTPase cycle Sema4D mediated inhibition of cell attachment and migration PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases	Other interleukin signaling
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Deep white matter hyperintensities ( 32517579)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		6 interacting genes: CDC42 GRB2 KRT31 PTPRZ1 RAC1 SRC	13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR
Entrez ID		2909	5803
HPRD ID		05592	01481
Ensembl ID		ENSG00000160007	ENSG00000106278
Uniprot IDs		Q9NRY4	B4DFE7 P23471
PDB IDs		2K85 3C5H 3FK2 6PXC 6WAY	3JXF 3S97 5AWX 5H08
Enriched GO Terms of Interacting Partners?
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