PTPRK and PTPRM

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PTPRK	PTPRM
Description		protein tyrosine phosphatase receptor type K	protein tyrosine phosphatase receptor type M
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Cell Surface Integral Component Of Membrane Cell Junction Leading Edge Membrane Intracellular Membrane-bounded Organelle	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Lamellipodium Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding Protein Kinase Binding Gamma-catenin Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Identical Protein Binding Cadherin Binding
	Biological Process	Protein Dephosphorylation Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Keratinocyte Proliferation Cell Migration Negative Regulation Of Cell Migration Protein Localization To Cell Surface Cellular Response To Reactive Oxygen Species Cellular Response To UV Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Focal Adhesion Assembly	Negative Regulation Of Endothelial Cell Proliferation Protein Dephosphorylation Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Negative Regulation Of Endothelial Cell Migration Retina Layer Formation Negative Regulation Of Angiogenesis Neuron Projection Development Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Response To Drug
Pathways		EGFR downregulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Asthma ( 31361310 31959851 30929738 32296059 31619474) Asthma (childhood onset) ( 30929738) Celiac disease ( 22057235 20190752 30572963) Crohn's disease ( 28067908) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Hodgkin's lymphoma ( 29196614) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Menarche (age at onset) ( 25231870) Metabolite levels ( 23823483) Multiple sclerosis ( 21833088) Nodular sclerosis Hodgkin lymphoma ( 29196614) Reaction time ( 29844566) Uterine fibroid size (maximum volume) ( 30196971) Waist circumference ( 28552196)	Adult body size ( 32376654) Benign childhood epilepsy with centro-temporal spikes ( 32580138) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Dialysis-related mortality ( 21546767) Estrone/androstenedione ratio in resected early stage-receptor positive breast cancer ( 28429243) Glucose homeostasis traits ( 25524916) Hippocampal volume ( 29860282) Huntington's disease progression ( 28642124) Iris heterochromicity ( 30895295) Lateral ventricle temporal horn volume ( 31530798) Midgestational circulating levels of PBDEs (fetal genetic effect) ( 28235828) Recurrence of mild malaria attacks ( 31667592) Response to methotrexate in rheumatoid arthritis ( 24583629) Sitting height ratio ( 25865494)
Interacting Genes		8 interacting genes: CSNK2B CTNNB1 GADD45A GADD45G JUP PSMD11 PTPRM TK1	11 interacting genes: BCCIP CDH1 CTNNB1 CTNND1 IQGAP1 PCSK5 PPFIBP1 PTPRA PTPRK PTPRS RACK1
Entrez ID		5796	5797
HPRD ID		03968	01479
Ensembl ID		ENSG00000152894	ENSG00000173482
Uniprot IDs		B4DHC3 Q15262 Q59EZ1 Q5TG12 Q86WJ2	P28827
PDB IDs		2C7S	1RPM 2C9A 2V5Y
Enriched GO Terms of Interacting Partners?
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