Description |
protein tyrosine phosphatase non-receptor type 11 |
AKT serine/threonine kinase 1 |
Image |
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Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
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- ATP
- Arsenic trioxide
- Genistein
- Inositol 1,3,4,5-Tetrakisphosphate
- Resveratrol
- Archexin
- Enzastaurin
- Perifosine
- N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
- 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
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Diseases |
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GWAS |
- Alcohol consumption (max-drinks) ( 29460428)
- Alcohol dependence symptom count ( 29460428)
- Apolipoprotein A1 levels ( 32203549)
- Blood pressure ( 21572416)
- Body mass index ( 26426971)
- Diastolic blood pressure ( 26390057)
- Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
- Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
- HDL cholesterol levels ( 32203549)
- Hematological parameters ( 19820697)
- Hypothyroidism ( 22493691)
- Low HDL-cholesterol levels ( 31006500)
- Mean arterial pressure ( 27618448)
- Medication use (agents acting on the renin-angiotensin system) ( 31015401)
- Medication use (beta blocking agents) ( 31015401)
- Medication use (diuretics) ( 31015401)
- Medication use (thyroid preparations) ( 31015401)
- Multiple sclerosis ( 31604244)
- Peripheral artery disease ( 31285632)
- Platelet count ( 22139419 32888494)
- Reaction time ( 29844566)
- Response to alcohol consumption (flushing response) ( 29460428)
- Retinal vascular caliber ( 21060863)
- Rheumatoid arthritis ( 30423114 24390342)
- Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655)
- Systolic blood pressure ( 26390057 30578418)
- Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858)
- Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
- Tetralogy of Fallot ( 23297363)
- Type 1 diabetes ( 17554300)
- Urate levels ( 23263486)
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Interacting Genes |
166 interacting genes:
AATK
ACTN4
AKT1
AR
ARHGAP1
AXL
BCR
BDKRB2
BEX1
BEX2
BLZF1
BTLA
CALR
CAT
CAV1
CBL
CCKBR
CD33
CDH5
CEACAM1
CHUK
CRKL
CSF2RB
CSF3R
CTDSP1
CTLA4
CXCR4
DAB1
DDR1
DMRTC1
EGFR
EPHA1
EPHA2
EPOR
ERBB2
ERBB3
ERBB4
FAM71E1
FBXW7
FCGR1B
FCGR2B
FCRL3
FGFR2
FGFR4
FLT1
FLT3
FLT4
FRS2
FRS3
FYN
GAB1
GAB2
GAB3
GHR
GMNN
GOLGA2
GRB2
GRIN2B
GTF2A2
HNRNPU
HSP90B1
HSPA5
HSPA9
HSPD1
IFNAR1
IFNGR1
IGF1R
IL4R
IL6ST
ILK
INPP5D
INSR
IRS1
IRS2
IRS4
JAK1
JAK2
KDR
KIR2DL5A
KIT
KLRC1
LAIR1
LCK
LEPR
LIFR
LILRB4
LINC01558
LINC02907
LNX1
LRP1
MAP3K4
MAP3K5
MAPK3
MAPT
MET
MPIG6B
MPL
MPZL1
MS4A2
MVP
NEB
NEDD9
NOX4
NSUN5
NSUN5P2
NTRK1
NTRK2
ORMDL3
PAG1
PDGFRA
PDGFRB
PECAM1
PIK3CA
PIK3CG
PIK3R1
PILRA
PILRB
PLCG1
PNCK
POU2AF1
PRKCA
PRKCB
PRKCH
PRLR
PTK2
PTK2B
PTK7
PTPN6
PXN
RANGRF
RET
ROR2
ROS1
RPIA
SELE
SERF2
SERPINF1
SHC1
SIGLEC11
SIGLEC12
SIGLEC7
SIRPA
SIT1
SLAMF1
SLAMF6
SLC38A1
SLN
SOCS3
SOS1
SPRY2
SRC
SRSF10
STAT1
STAT3
STAT5A
STAT5B
SYNCRIP
TEK
TIE1
TLK1
TNFRSF1A
TREML1
TRIM32
TRMT2B
TSC2
TXNIP
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319 interacting genes:
ACAP1
ACAT2
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
APLP2
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARNT
ATXN1
AURKA
BABAM1
BAD
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BEX1
BLVRA
BPGM
BRAF
BRCA1
BUB1
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CD44
CDC37
CDH1
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CNOT9
CREB1
CREBBP
CSNK2A1
CTDSP2
CTNNA1
CTNNB1
CYLD
DAB2IP
DCTN1
DDIT4L
DLC1
DNAJB1
DNMT1
EEF1G
EIF4EBP1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FANCA
FANCI
FASN
FBXO31
FBXW7
FGFR4
FOXO1
FOXO3
FOXO4
FUS
FZR1
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ITGB3
ITPR1
ITPR3
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK14
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MATK
MDM2
MDM4
MESD
METTL1
MLH3
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCOA4
NCOR2
NF1
NF2
NGB
NOL4
NOS3
NOTCH1
NR4A1
NRAS
NSD3
OSGIN1
PAK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PMS2
PPARGC1B
PPL
PPM1A
PPP2CA
PPP2R1A
PRG2
PRKCQ
PRKCZ
PRKDC
PSMC5
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYGO2
RAB3D
RAC1
RAF1
RARA
RASL10B
RASSF1
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
S100A14
S1PR1
SERPINB5
SETDB1
SH2B2
SH3RF1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS2
SOX2
SOX4
SP1
SP3
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TLR2
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRIB3
TRIM13
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
USP4
UXS1
VEGFA
VHL
VIM
WNK1
WNK4
XAF1
XIAP
YAP1
YBX1
YWHAZ
ZFP36L1
ZHX1
ZNF691
ZRANB1
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Entrez ID |
5781 |
207 |
HPRD ID |
01470 |
01261 |
Ensembl ID |
ENSG00000179295
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ENSG00000142208
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Uniprot IDs |
Q06124
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B0LPE5
B3KVH4
P31749
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PDB IDs |
2SHP
3B7O
3MOW
3O5X
3TKZ
3TL0
3ZM0
3ZM1
3ZM2
3ZM3
4DGP
4DGX
4GWF
4H1O
4H34
4JE4
4JEG
4JMG
4NWF
4NWG
4OHD
4OHE
4OHH
4OHI
4OHL
4PVG
4QSY
4RDD
5BK8
5DF6
5EHP
5EHR
5I6V
5IBM
5IBS
5X7B
5X94
5XZR
6ATD
6BMR
6BMU
6BMV
6BMW
6BMX
6BMY
6BN5
6CMP
6CMQ
6CMR
6CMS
6CRF
6CRG
6IHZ
6MD7
6MD9
6MDA
6MDB
6MDC
6MDD
6R5G
7JVM
7JVN
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1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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