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AKT1 and HSPB1
Data Source:
BioGRID
(pull down, enzymatic study, affinity chromatography technology)
AKT1
HSPB1
Description
AKT serine/threonine kinase 1
heat shock protein family B (small) member 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Spindle
Cytosol
Plasma Membrane
Cell-cell Junction
Microtubule Cytoskeleton
Lamellipodium
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Vesicle
Protein-containing Complex
Ciliary Basal Body
Postsynapse
Proteasome Complex
Extracellular Space
Nucleus
Cytoplasm
Spindle
Cytosol
Cytoskeleton
Focal Adhesion
Extracellular Exosome
Axon Cytoplasm
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Serine/threonine/tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
Calmodulin Binding
ATP Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Kinase Activity
Enzyme Binding
Nitric-oxide Synthase Regulator Activity
GTPase Activating Protein Binding
Identical Protein Binding
Protein Homodimerization Activity
Phosphatidylinositol-3,4-bisphosphate Binding
Protein Phosphatase 2A Binding
14-3-3 Protein Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
RNA Binding
Protein Kinase C Binding
Protein Binding
Protein Kinase C Inhibitor Activity
Protein Kinase Binding
Identical Protein Binding
Protein Homodimerization Activity
Ubiquitin Binding
Protein Folding Chaperone
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Biological Process
Osteoblast Differentiation
Maternal Placenta Development
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Sphingosine-1-phosphate Receptor Signaling Pathway
Glycogen Biosynthetic Process
Regulation Of Glycogen Biosynthetic Process
Glucose Metabolic Process
Translation
Regulation Of Translation
Protein Phosphorylation
Negative Regulation Of Protein Kinase Activity
Protein Import Into Nucleus
Nitric Oxide Biosynthetic Process
Activation-induced Cell Death Of T Cells
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Germ Cell Development
Aging
Cell Population Proliferation
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Apoptotic Mitochondrial Changes
Carbohydrate Transport
Response To Heat
Negative Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane
Fibroblast Migration
Positive Regulation Of Fibroblast Migration
Positive Regulation Of Sodium Ion Transport
Positive Regulation Of Glucose Metabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Negative Regulation Of Endopeptidase Activity
Regulation Of Neuron Projection Development
Phosphatidylinositol 3-kinase Signaling
Negative Regulation Of Macroautophagy
Phosphorylation
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Cytokine-mediated Signaling Pathway
Spinal Cord Development
Cell Projection Organization
Cell Differentiation
Protein Catabolic Process
Hyaluronan Metabolic Process
Positive Regulation Of Cell Growth
Regulation Of Cell Migration
Endocrine Pancreas Development
T Cell Costimulation
Negative Regulation Of Protein Ubiquitination
Regulation Of Myelination
Lipopolysaccharide-mediated Signaling Pathway
TOR Signaling
Negative Regulation Of Fatty Acid Beta-oxidation
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Response To Food
Activation Of Protein Kinase B Activity
Positive Regulation Of Cellular Protein Metabolic Process
Peripheral Nervous System Myelin Maintenance
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cellular Response To Insulin Stimulus
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Fluid Shear Stress
Cellular Response To Reactive Oxygen Species
Intracellular Signal Transduction
Interleukin-18-mediated Signaling Pathway
Cellular Response To Vascular Endothelial Growth Factor Stimulus
NIK/NF-kappaB Signaling
Glucose Homeostasis
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Anoikis
Regulation Of MRNA Stability
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of Glycogen Biosynthetic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Notch Signaling Pathway
Negative Regulation Of Cell Size
Negative Regulation Of Proteolysis
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Vasoconstriction
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Glucose Import
Negative Regulation Of JNK Cascade
Positive Regulation Of Organ Growth
Protein Autophosphorylation
Positive Regulation Of Lipid Biosynthetic Process
Insulin-like Growth Factor Receptor Signaling Pathway
Positive Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of Nitric-oxide Synthase Activity
Positive Regulation Of DNA-binding Transcription Factor Activity
Striated Muscle Cell Differentiation
Negative Regulation Of Protein Kinase B Signaling
Excitatory Postsynaptic Potential
Response To Growth Hormone
Mammary Gland Epithelial Cell Differentiation
Labyrinthine Layer Blood Vessel Development
Response To UV-A
Cellular Response To Mechanical Stimulus
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Organic Cyclic Compound
Cellular Response To Hypoxia
Negative Regulation Of Protein Serine/threonine Kinase Activity
Establishment Of Protein Localization To Mitochondrion
Maintenance Of Protein Location In Mitochondrion
Negative Regulation Of Release Of Cytochrome C From Mitochondria
Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Execution Phase Of Apoptosis
Negative Regulation Of Protein Kinase Activity By Protein Phosphorylation
Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus
Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Positive Regulation Of Protein Localization To Nucleus
Negative Regulation Of Neuron Death
Regulation Of Signal Transduction By P53 Class Mediator
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Negative Regulation Of Leukocyte Cell-cell Adhesion
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of I-kappaB Phosphorylation
Cellular Response To Nerve Growth Factor Stimulus
Response To Insulin-like Growth Factor Stimulus
Positive Regulation Of Protein Localization To Cell Surface
Negative Regulation Of Lymphocyte Migration
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Retina Homeostasis
Regulation Of Protein Phosphorylation
Regulation Of Translational Initiation
Negative Regulation Of Protein Kinase Activity
Response To Unfolded Protein
Response To Virus
Regulation Of Autophagy
Viral Process
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Tumor Necrosis Factor Production
Intracellular Signal Transduction
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Regulation Of MRNA Stability
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Positive Regulation Of Angiogenesis
Chaperone-mediated Protein Folding
Platelet Aggregation
Negative Regulation Of Protein Serine/threonine Kinase Activity
Anterograde Axonal Protein Transport
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Endothelial Cell Chemotaxis
Pathways
Activation of BAD and translocation to mitochondria
PIP3 activates AKT signaling
PIP3 activates AKT signaling
Downregulation of ERBB2:ERBB3 signaling
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
MTOR signalling
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the cytosol
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in Cancer
Interleukin-4 and Interleukin-13 signaling
Regulation of TP53 Degradation
Regulation of TP53 Activity through Acetylation
Regulation of TP53 Activity through Association with Co-factors
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Cyclin E associated events during G1/S transition
Cyclin A:Cdk2-associated events at S phase entry
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
RAB GEFs exchange GTP for GDP on RABs
RUNX2 regulates genes involved in cell migration
Regulation of PTEN stability and activity
Extra-nuclear estrogen signaling
Negative regulation of NOTCH4 signaling
FLT3 Signaling
Regulation of localization of FOXO transcription factors
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
VEGFA-VEGFR2 Pathway
AUF1 (hnRNP D0) binds and destabilizes mRNA
MAPK6/MAPK4 signaling
Extra-nuclear estrogen signaling
Drugs
ATP
Arsenic trioxide
Genistein
Inositol 1,3,4,5-Tetrakisphosphate
Resveratrol
Archexin
Enzastaurin
Perifosine
N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
Apatorsen
Artenimol
Phenethyl Isothiocyanate
Diseases
PTEN hamartoma tumor syndrome (PHTS), including: Cowden syndrome; Bannayan-Riley-Ruvalcaba syndrome; Proteus syndrome; Proteus-like syndrome
Distal hereditary motor neuropathies (dHMN)
GWAS
Apolipoprotein A1 levels (
32203549
)
Endometrial cancer (
27135401
)
Endometrial endometrioid carcinoma (
27135401
)
HDL cholesterol (
24097068
30275531
25961943
)
HDL cholesterol levels (
32203549
28334899
)
Neutrophil count (
32888494
)
Blood protein levels (
30072576
)
Blood protein levels in cardiovascular risk (
28369058
)
Schizophrenia (
30285260
)
Interacting Genes
319 interacting genes:
ACAP1
ACAT2
AGAP2
AGR3
AHNAK
AHSA1
AKT1S1
AKT2
AKTIP
ALYREF
APLP2
APOH
APP
APPL1
AR
ARAF
ARFIP2
ARNT
ATXN1
AURKA
BABAM1
BAD
BCL10
BCL2L1
BCL2L11
BCL3
BECN1
BEX1
BLVRA
BPGM
BRAF
BRCA1
BUB1
CAMKK1
CARHSP1
CASC3
CASP3
CASP9
CBLC
CCDC88A
CCND2
CCNE1
CCNF
CCNI
CD44
CDC37
CDH1
CDK4
CDK6
CDKN1A
CDKN1B
CDKN1C
CDKN2A
CDKN2B
CDKN2C
CEP57L1
CEP76
CHEK1
CHUK
CLASP2
CLIP3
CLK2
CNOT9
CREB1
CREBBP
CSNK2A1
CTDSP2
CTNNA1
CTNNB1
CYLD
DAB2IP
DCTN1
DDIT4L
DLC1
DNAJB1
DNMT1
EEF1G
EIF4EBP1
EMSY
ENO2
EP300
EPHA2
EPSTI1
ERBB2
ESR1
ESR2
EZH2
FAF1
FANCA
FANCI
FASN
FBXO31
FBXW7
FGFR4
FOXO1
FOXO3
FOXO4
FUS
FZR1
GAB2
GATA1
GATA2
GET4
GFAP
GJA1
GLIS2
GRB10
GRIN2A
GSK3A
GSK3B
H2BC21
H2BC3
HIF1A
HMOX1
HSP90AA1
HSP90AB1
HSPB1
HTT
IKBKB
IL13RA2
IL24
ILK
IMPDH2
IRAK1
IRS1
ITGB3
ITPR1
ITPR3
IWS1
JADE1
KANK1
KAT2A
KAT2B
KAT6A
KDELR2
KLHL3
KMT2D
KRT10
LANCL2
LATS2
LRRK2
LTB4R2
MAP2K3
MAP2K4
MAP2K5
MAP2K6
MAP3K11
MAP3K5
MAP3K8
MAPK14
MAPK8
MAPK8IP1
MAPK9
MAPKAP1
MAPKAPK2
MAPT
MATK
MDM2
MDM4
MESD
METTL1
MLH3
MRC2
MS4A2
MSH2
MST1R
MTA3
MTCP1
MTOR
MTUS2
MUL1
MXD1
MYC
NCF2
NCOA4
NCOR2
NF1
NF2
NGB
NOL4
NOS3
NOTCH1
NR4A1
NRAS
NSD3
OSGIN1
PAK1
PDE3A
PDE3B
PDGFRA
PDHB
PDK1
PDK2
PDPK1
PEA15
PFKFB1
PFKFB2
PFKP
PHB2
PI4K2B
PIAS1
PIAS2
PICK1
PIK3CA
PIK3R1
PIP5K1C
PKN2
PLCG1
PLEKHO1
PLP1
PLXNA1
PMS2
PPARGC1B
PPL
PPM1A
PPP2CA
PPP2R1A
PRG2
PRKCQ
PRKCZ
PRKDC
PSMC5
PTEN
PTGDS
PTPA
PTPN1
PTPN11
PTPN3
PYGO2
RAB3D
RAC1
RAF1
RARA
RASL10B
RASSF1
RGCC
RHEBL1
RNF11
RNF115
RPS6KB1
S100A14
S1PR1
SERPINB5
SETDB1
SH2B2
SH3RF1
SIRPA
SIRT1
SIRT6
SKI
SKP2
SLC9A3R1
SMAD2
SMAD3
SMAD4
SMAD7
SMARCB1
SMARCC1
SNCA
SNCB
SORBS2
SOX2
SOX4
SP1
SP3
SRC
SRPK2
SRR
SSH1
ST14
STAT1
STK11
STK3
STK4
SULT4A1
SUPT6H
SYTL1
TBC1D4
TBC1D7
TCL1A
TCL1B
TCL6
TEAD2
TERF2IP
TERT
TFF1
THEM4
THRSP
TLR2
TMCC2
TNFRSF1A
TNFSF11
TNK2
TOPBP1
TP53
TRIB3
TRIM13
TRMT2B
TSC1
TSC2
TTC3
UBE2S
UCHL1
USP4
UXS1
VEGFA
VHL
VIM
WNK1
WNK4
XAF1
XIAP
YAP1
YBX1
YWHAZ
ZFP36L1
ZHX1
ZNF691
ZRANB1
254 interacting genes:
ACAP2
ACBD6
ACTC1
ACTN1
ACTN2
ACTN4
ADCY9
ADD3
ADPRS
AGAP10P
AGAP3
AGAP4
AGAP5
AGAP7P
AKT1
ALPI
AMD1
ANAPC7
ANK1
ANKRD7
ANXA1
AP2B1
APPL1
ARHGAP28
ARHGEF7
ARIH1
ARMT1
ARRDC5
ATXN10
BAG3
BICDL1
BVES
C11orf98
C2orf73
CAMK1
CBX1
CCDC32
CCDC70
CCHCR1
CCNC
CCNDBP1
CCNO
CDC123
CDK5RAP3
CENPK
CEP78
CETN3
CFAP251
CLCN3
CPSF3
CRNKL1
CRYAA
CRYAB
CRYBB2
CRYGC
CS
CYCS
DAXX
DES
DMAP1
DNAJC21
ECPAS
EHD1
EIF1AX
EIF2S1
EIF3M
EIF4G1
EIF4G3
EIF5
ENPP2
EPB41L1
EPB41L2
EPB41L3
ERCC5
ERICH6
ESR1
FAM71D
FLNB
FXR1
GAPVD1
GDI2
GLMN
GNPAT
GOLGA8A
GRIPAP1
GRK3
GSTO1
GTSF1
GUCA1A
HAUS8
HDLBP
HECTD1
HNRNPA2B1
HNRNPD
HNRNPF
HNRNPU
HSP90AB1
HSPA4
HSPA5
HSPB8
HUWE1
IARS2
IGBP1
IGSF21
INPP5K
INS
ISG20L2
KANSL1
KCMF1
KCTD3
KLC1
KNSTRN
KPNA3
KRT18
KRT72
LBP
LIG1
LONRF1
LRIF1
LSM3
LUZP1
MAPK14
MAPKAPK2
MAPKAPK3
MAPKAPK5
MAPT
MCM6
MDH2
MED31
MFAP1
MPHOSPH6
MRGBP
MRPL28
MRPL40
MRPS23
MSL1
MTIF2
MYG1
MYL12A
MYL12B
MYL9
MYLK
NAP1L1
NAPA
NBAS
NCKIPSD
NEK10
NEXN
NFKBIA
NFU1
NSMCE4A
NVL
OBSL1
OPTN
OSBPL9
PAF1
PALM3
PELO
PGM2
PHYHIPL
PLG
PNISR
PNPT1
POP7
PPA1
PPM1A
PPP2R3C
PRPF19
PRPF40A
PSMA3
PSMA6
PSMB2
PSMC1
PSMD1
PTGES3
PTPN3
PTPRA
RAB41
RAD23A
RALA
RASSF9
RBM25
RBM39
RBM48
RBPJ
RPAP3
RPSA
RSPH3
RYBP
S100A4
SAT1
SBF1
SEC13
SERTAD1
SF3A3
SF3B3
SLC7A9
SMARCA2
SMARCA4
SMARCD1
SNRNP200
SNRPF
SPACA7
SPATA7
SPIN1
SPTBN1
SQSTM1
SRP72
STUB1
SUMO2
SUPT5H
SYCE1
TARBP2
TARS1
TBC1D1
TBC1D3B
TGFB1I1
TGM1
THOC5
TJP2
TMCO3
TOMM70
TOX4
TP53
TPT1
TRIM24
TRIM54
TRIM55
TRIM63
TSNAXIP1
TTC3
TTC39C
TXNL1
UCHL5
UFD1
UQCC2
UQCRB
VIM
WASHC3
WDR83
WWP1
XPO1
XRCC5
YWHAB
YWHAE
YWHAH
YWHAQ
YWHAZ
ZBTB17
ZBTB37
ZFAT
ZNF131
ZNF197
ZNRF3
Entrez ID
207
3315
HPRD ID
01261
09076
Ensembl ID
ENSG00000142208
ENSG00000106211
Uniprot IDs
B0LPE5
B3KVH4
P31749
P04792
V9HW43
PDB IDs
1H10
1UNP
1UNQ
1UNR
2UVM
2UZR
2UZS
3CQU
3CQW
3MV5
3MVH
3O96
3OCB
3OW4
3QKK
3QKL
3QKM
4EJN
4EKK
4EKL
4GV1
5KCV
6BUU
6CCY
6HHF
6HHG
6HHH
6HHI
6HHJ
6NPZ
6S9W
6S9X
2N3J
3Q9P
3Q9Q
4MJH
6DV5
6GJH
Enriched GO Terms of Interacting Partners
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