SPTBN4 and NEK2

Data Source:
BioGRID (two hybrid)

		SPTBN4	NEK2
Description		spectrin beta, non-erythrocytic 4	NIMA related kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber	Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein-containing Complex
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Cytoskeletal Protein-membrane Anchor Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	MAPK Cascade Regulation Of Sodium Ion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane	Mitotic Sister Chromatid Segregation G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Positive Regulation Of Telomerase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Ciliary Basal Body-plasma Membrane Docking Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Telomere Capping
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs			5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases
GWAS		Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)	Red cell distribution width ( 32888494 27863252 28957414)
Interacting Genes		15 interacting genes: ANK3 ARC CDC37 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1	28 interacting genes: CCDC85A CDC20 CEP250 CHGA CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		57731	4751
HPRD ID		09372	04953
Ensembl ID		ENSG00000160460	ENSG00000117650
Uniprot IDs		Q9H254	F6U4U2 P51955
PDB IDs			2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5
Enriched GO Terms of Interacting Partners?
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