SPTBN4 and GADD45A

Data Source:
BioGRID (two hybrid)

		SPTBN4	GADD45A
Description		spectrin beta, non-erythrocytic 4	growth arrest and DNA damage inducible alpha
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Actin Filament Plasma Membrane Adherens Junction Spectrin Intercalated Disc Membrane Nuclear Matrix PML Body Node Of Ranvier Paranode Region Of Axon Neuronal Cell Body Axon Initial Segment Axon Hillock Extracellular Exosome Cell Body Fiber	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Phospholipid Binding Phosphatase Binding Ankyrin Binding Spectrin Binding Cytoskeletal Protein-membrane Anchor Activity	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding Promoter-specific Chromatin Binding
	Biological Process	MAPK Cascade Regulation Of Sodium Ion Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axonogenesis Axon Guidance Sensory Perception Of Sound Adult Walking Behavior Fertilization Negative Regulation Of Heart Rate Vesicle-mediated Transport Transmission Of Nerve Impulse Central Nervous System Projection Neuron Axonogenesis Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Multicellular Organism Growth Clustering Of Voltage-gated Sodium Channels Actin Filament Capping Cardiac Conduction Protein Localization To Plasma Membrane	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPKKK Activity DNA Repair Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Mitotic Cell Cycle Arrest Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Antibody level in response to infection ( 25758998) Carotid intima media thickness (mean) ( 31801372) Hemoglobin levels ( 32327693) Pulse pressure ( 30578418)	Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		15 interacting genes: ANK3 ARC CDC37 CELSR3 CENPU CLK1 DISC1 GADD45A GSK3B NEK2 PFDN1 PTPRN PTPRN2 RPS6KA6 SPTAN1	69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4-16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		57731	1647
HPRD ID		09372	00528
Ensembl ID		ENSG00000160460	ENSG00000116717
Uniprot IDs		Q9H254	A5JUZ3 P24522
PDB IDs			2KG4
Enriched GO Terms of Interacting Partners?
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