QSOX1 and CCR6

Data Source:
BioGRID (two hybrid)

		QSOX1	CCR6
Description		quiescin sulfhydryl oxidase 1	C-C motif chemokine receptor 6
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Integral Component Of Golgi Membrane Platelet Alpha Granule Lumen Specific Granule Lumen Intracellular Membrane-bounded Organelle Intercellular Bridge Extracellular Exosome Tertiary Granule Lumen	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Sperm Flagellum Sperm Midpiece Sperm Principal Piece Sperm Plasma Membrane
	Molecular Function	Protein Disulfide Isomerase Activity Flavin-linked Sulfhydryl Oxidase Activity FAD Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding Signaling Receptor Activity
	Biological Process	Platelet Degranulation Protein Folding Negative Regulation Of Macroautophagy Protein Phosphopantetheinylation Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process Extracellular Matrix Assembly	Dendritic Cell Chemotaxis Leukocyte Migration Involved In Inflammatory Response Chemotaxis Immune Response Humoral Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Epithelial Cell Migration Calcium-mediated Signaling Isotype Switching To IgA Isotypes Cell Chemotaxis Positive Regulation Of Flagellated Sperm Motility Involved In Capacitation Chemokine-mediated Signaling Pathway Lymphocyte Migration T Cell Migration Thymocyte Migration DN2 Thymocyte Differentiation DN3 Thymocyte Differentiation Regulation Of T Cell Migration Positive Regulation Of Dendritic Cell Chemotaxis
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Anorexia nervosa ( 23568457) Blood protein levels ( 29875488) Pulse pressure ( 30224653 30578418)	Albumin-globulin ratio ( 29403010) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Basal cell carcinoma ( 31174203) Crohn's disease ( 18587394 28067908 20570966 21102463 23850713) Graves' disease ( 22922229) Inflammatory bowel disease ( 27569725 28067908 23128233) Keratinocyte cancer (MTAG) ( 31174203) Lung cancer ( 28604730) Primary biliary cholangitis ( 28425483) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Rheumatoid arthritis ( 30423114 24782177 23143596 24390342 20453841 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Social autistic-like traits ( 24133439) Triglycerides ( 24886709) Vitiligo ( 20526339 27723757)
Interacting Genes		6 interacting genes: BEGAIN CCR1 CCR6 CHRM4 UBE2D2 UBQLN4	5 interacting genes: CCL20 DEFB1 DEFB103B DEFB4A QSOX1
Entrez ID		5768	1235
HPRD ID		06785	03498
Ensembl ID		ENSG00000116260	ENSG00000112486
Uniprot IDs		A0A140VKE5 O00391 Q13876	P51684
PDB IDs		3LLI 3LLK 3Q6O 4IJ3	6WWZ
Enriched GO Terms of Interacting Partners?
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