PLEKHA4 and MEI4

Data Source:
BioGRID (two hybrid)

		PLEKHA4	MEI4
Description		pleckstrin homology domain containing A4	meiotic double-stranded break formation protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Lateral Element
	Molecular Function	Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Protein Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis
Pathways		Synthesis of PIPs at the plasma membrane
Drugs		Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)	Brain volume in infants (white matter) ( 28763065) Cadmium levels ( 26025379) Macular thickness ( 30535121)
Interacting Genes		8 interacting genes: ABL1 CCNG1 EEF1G KAT5 KLHL12 LRIF1 MEI4 SETDB1	36 interacting genes: AFMID BAG4 C19orf25 C1orf109 CABP5 CDKN2D CHAF1A CPNE2 CST9L CTTNBP2 DNTT EIF5A FKBP6 GRB2 HSD3B7 IQGAP1 LGALS14 MACO1 METTL21A MLX MTMR9 MYO5B NGB NME7 OSGIN1 PAFAH1B3 PHYHIPL PLEKHA4 POLR1C R3HDM2 TRAPPC2L TRIM59 TSEN15 TSSK3 USHBP1 VPS26C
Entrez ID		57664	101928601
HPRD ID		09683
Ensembl ID		ENSG00000105559	ENSG00000269964
Uniprot IDs		Q9H4M7	A8MW99
PDB IDs		1UPQ 1UPR
Enriched GO Terms of Interacting Partners?
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