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MEI4 and POLR1C
Data Source:
BioGRID
(two hybrid)
MEI4
POLR1C
Description
meiotic double-stranded break formation protein 4
RNA polymerase I and III subunit C
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Lateral Element
Nucleoplasm
RNA Polymerase III Complex
RNA Polymerase I Complex
Cytosol
Molecular Function
Protein Binding
RNA Polymerase I Activity
RNA Polymerase III Activity
DNA Binding
DNA-directed 5'-3' RNA Polymerase Activity
Protein Binding
Protein Dimerization Activity
Biological Process
DNA Recombination
Homologous Chromosome Pairing At Meiosis
Spermatogenesis
Meiotic DNA Double-strand Break Formation
Oogenesis
Transcription By RNA Polymerase I
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase III
Positive Regulation Of Type I Interferon Production
Positive Regulation Of Gene Expression, Epigenetic
Pathways
Cytosolic sensors of pathogen-associated DNA
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase III Chain Elongation
RNA Polymerase I Transcription Termination
RNA Polymerase III Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases
Treacher Collins syndrome
GWAS
Brain volume in infants (white matter) (
28763065
)
Cadmium levels (
26025379
)
Macular thickness (
30535121
)
GLP-1 levels in response to oral glucose tolerance test (fasting) (
29093273
)
Waist-to-hip ratio adjusted for BMI (
26426971
)
Waist-to-hip ratio adjusted for BMI (age <50) (
26426971
)
Waist-to-hip ratio adjusted for BMI (age >50) (
26426971
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
36 interacting genes:
AFMID
BAG4
C19orf25
C1orf109
CABP5
CDKN2D
CHAF1A
CPNE2
CST9L
CTTNBP2
DNTT
EIF5A
FKBP6
GRB2
HSD3B7
IQGAP1
LGALS14
MACO1
METTL21A
MLX
MTMR9
MYO5B
NGB
NME7
OSGIN1
PAFAH1B3
PHYHIPL
PLEKHA4
POLR1C
R3HDM2
TRAPPC2L
TRIM59
TSEN15
TSSK3
USHBP1
VPS26C
119 interacting genes:
ADAMTSL4
ARHGEF5
ATRIP
AVPI1
BHLHB9
BIN3
BIRC7
BLZF1
C1orf105
C21orf58
C4orf45
CBX8
CBY2
CCDC33
CCNK
CCT3
CGGBP1
CLU
CORO1A
CORO1B
CRACR2A
EFHC2
EP400
FH
FMR1
FOXR2
GAS8
GMPPB
GOLGA6A
GOLGA6L9
GRPEL1
GSTO2
HDX
HNRNPH1
HOXB9
HOXD12
IHO1
IKZF3
INCA1
KCTD1
KCTD13
KLF15
KRT19
KRT75
KRT76
KRTAP12-2
KRTAP3-1
LNX2
LRIF1
LZTS1
LZTS2
MBIP
MEI4
MEOX2
MKRN3
MORN3
MRPS23
MYD88
MYO5B
NDUFB10
NEDD4
NFKBIB
NIF3L1
NME1
NME4
PIH1D2
POLDIP3
POLR1D
POLR1E
POLR1G
POLR2G
POLR2J
POLR2J3
PPP2R3C
PSMA1
RBM48
RIMBP3
RIMBP3C
RSPH14
RUSC1
SAXO1
SMN1
SMN2
SORBS3
SPATC1L
SPRY1
STMN3
TASOR2
TAX1BP1
TCF4
TEX43
TFIP11
TLE5
TMEM121
TNFAIP1
TNNI1
TRAIP
TRIM14
TRIM27
TRIOBP
TSC22D4
UNKL
USP54
VIM
WASHC1
WRN
XPA
YPEL3
ZBED1
ZBTB42
ZC2HC1C
ZFP57
ZIM2
ZNF547
ZNF554
ZNF655
ZNF688
ZNF835
ZRANB1
Entrez ID
101928601
9533
HPRD ID
09661
Ensembl ID
ENSG00000269964
ENSG00000171453
Uniprot IDs
A8MW99
O15160
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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