SH3RF1 and EAF1

Data Source:
BioGRID (two hybrid)

		SH3RF1	EAF1
Description		SH3 domain containing ring finger 1	ELL associated factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Nucleoplasm Transcription Elongation Factor Complex Cajal Body Nuclear Body Nuclear Speck Super Elongation Complex Intracellular Membrane-bounded Organelle Intercellular Bridge
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Elongation Regulator Activity Protein Binding
	Biological Process	Neuron Migration Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	53 interacting genes: AP2M1 APP ARID4B BEND7 BHLHB9 CCDC150 CCDC33 CEP70 CEP76 DNTTIP1 DPPA4 ELL ELL2 ELL3 FAM228A GADD45GIP1 GAS8 GCSAML GOLGA6L9 GRHL3 GTF2H1 GTF2H4 HOMER3 HSF2BP KEAP1 KIAA1328 MAB21L3 MIPOL1 NUMB PAX6 PICK1 PIH1D1 PSME3 RYBP SDCBP SEMG1 SH3RF1 SRP14 STAC3 TCEA2 TFCP2 TFPT TLE5 TNFAIP8 TNNI1 TRAF2 TRIM62 VAX1 YAF2 ZBTB14 ZNF143 ZNF202 ZNF620
Entrez ID		57630	85403
HPRD ID		15335	12209
Ensembl ID		ENSG00000154447	ENSG00000144597
Uniprot IDs		Q7Z6J0	Q96JC9
PDB IDs
Enriched GO Terms of Interacting Partners?
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