SH3RF1 and MAP3K9

Data Source:
HPRD (in vitro)

		SH3RF1	MAP3K9
Description		SH3 domain containing ring finger 1	mitogen-activated protein kinase kinase kinase 9
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Cytosol Lamellipodium Perinuclear Region Of Cytoplasm	Cellular_component
	Molecular Function	MAP-kinase Scaffold Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity
	Biological Process	Neuron Migration Viral Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of JNK Cascade Protein Autoubiquitination Regulation Of CD8-positive, Alpha-beta T Cell Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Protein Phosphorylation Apoptotic Process Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Apoptotic Process Protein Autophosphorylation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs			12-(2-hydroxyethyl)-2-(1-methylethoxy)-13,14-dihydronaphtho[2,1-a]pyrrolo[3,4-c]carbazol-5(12H)-one Fostamatinib
Diseases
GWAS		Alzheimer disease and age of onset ( 26830138) Body fat mass ( 28552196) Body mass index ( 28552196) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Night sleep phenotypes ( 27126917) Photic sneeze reflex ( 27182965) Schizophrenia ( 30285260) Weight ( 28552196)	Anthropometric traits (multi-trait analysis) ( 30166351) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309)
Interacting Genes		69 interacting genes: ACAP1 ADAM15 AKT1 AKT2 ARHGEF15 ATN1 ATXN7L2 CBLB CCDC6 DLGAP4 DMRTB1 DNM2 EAF1 EVL FGD1 FHL2 GGN HERPUD1 KCNJ1 LCP2 MAP3K10 MAP3K11 MAP3K12 MAP3K9 MAP4K3 MTURN NAF1 NCF1 NFKBID NHSL2 NUTM2F ONECUT3 PAK2 PDCD6IP PRAM1 PRB3 PRR20A PRR20B PRR20C PRR20D PRR20E PXN RAC1 RACGAP1 RAD23A RIN1 RNF208 RUNX1T1 SEMA6A SF3A2 SH2D4A SH3BP2 SH3D19 SIAH1 SLC22A5 SOCS7 SORBS2 SUFU SYNPO2L TP53BP2 UBASH3A UBE2D1 UBE2D3 UBE2K UBE2N VPS37C WASL WIPF1 XIRP1	2 interacting genes: SH3RF1 SMURF1
Entrez ID		57630	4293
HPRD ID		15335	15965
Ensembl ID		ENSG00000154447	ENSG00000006432
Uniprot IDs		Q7Z6J0	A0A087WW79 B4DZC4 G3V347 J3KPI6 P80192 Q8NEB1
PDB IDs			3DTC 4UY9
Enriched GO Terms of Interacting Partners?
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