MRTFA and MYOCD

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		MRTFA	MYOCD
Description		myocardin related transcription factor A	myocardin
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus
	Molecular Function	Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding
	Biological Process	Positive Regulation Of Transcription Via Serum Response Element Binding Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Regulation Of Histone Acetylation Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of DNA Binding Cellular Component Maintenance Regulation Of Myoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Positive Regulation Of DNA-binding Transcription Factor Activity Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Negative Regulation Of Cell Adhesion Molecule Production Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation
Pathways		SUMOylation of transcription cofactors RHO GTPases Activate Formins
Drugs		Latrunculin B
Diseases
GWAS			Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) PR interval ( 30679814 30046033 32439900) QRS duration ( 31251759) Systolic blood pressure change trajectories ( 27980656) Testosterone levels ( 22675492)
Interacting Genes		10 interacting genes: KDM3A MRTFB MVP MYOCD NCOA3 SMARCA4 SRF SUMO1 TRIM54 UBE2I	11 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 SMAD2 SMAD3 SMARCA4 SRF STUB1
Entrez ID		57591	93649
HPRD ID		10445	09362
Ensembl ID		ENSG00000196588	ENSG00000141052
Uniprot IDs		A4FUJ8 E7ER32 Q969V6 W0Z7M9	Q8IZQ8
PDB IDs		2KVU 2KW9
Enriched GO Terms of Interacting Partners?
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