MYOCD and STUB1

Data Source:
BioGRID (imaging technique, enzymatic study)

		MYOCD	STUB1
Description		myocardin	STIP1 homology and U-box containing protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Z Disc Ubiquitin Conjugating Enzyme Complex Nuclear Inclusion Body Chaperone Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding Histone Acetyltransferase Binding Histone Deacetylase Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding R-SMAD Binding	G Protein-coupled Receptor Binding Ubiquitin-protein Transferase Activity Protein Binding Enzyme Binding Kinase Binding Hsp70 Protein Binding Protein-macromolecule Adaptor Activity TPR Domain Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Protein Homodimerization Activity SMAD Binding Tau Protein Binding Chaperone Binding Misfolded Protein Binding Hsp90 Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth By Extracellular Stimulus Vasculogenesis Response To Hypoxia Cardiac Ventricle Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cardiocyte Differentiation Regulation Of Histone Acetylation Vascular Associated Smooth Muscle Cell Differentiation Positive Regulation Of DNA Binding Cellular Component Maintenance Regulation Of Myoblast Differentiation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Smooth Muscle Contraction Lung Alveolus Development Digestive Tract Development Positive Regulation Of DNA-binding Transcription Factor Activity Smooth Muscle Cell Differentiation Regulation Of Smooth Muscle Cell Differentiation Positive Regulation Of Smooth Muscle Cell Differentiation Cardiac Muscle Cell Differentiation Ventricular Cardiac Muscle Cell Differentiation Uterus Development Urinary Bladder Development Negative Regulation Of Cell Adhesion Molecule Production Ductus Arteriosus Closure Negative Regulation Of Amyloid-beta Clearance Regulation Of Phenotypic Switching Positive Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Differentiation Negative Regulation Of Skeletal Muscle Cell Differentiation	Protein Polyubiquitination Response To Ischemia DNA Repair Ubiquitin-dependent Protein Catabolic Process Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Protein Ubiquitination Regulation Of Protein Stability Regulation Of Glucocorticoid Metabolic Process Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Heat ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of Ubiquitin-protein Transferase Activity Protein Maturation Protein Autoubiquitination Chaperone-mediated Autophagy Protein K63-linked Ubiquitination Cellular Response To Misfolded Protein Cellular Response To Hypoxia Positive Regulation Of Chaperone-mediated Protein Complex Assembly
Pathways			Downregulation of TGF-beta receptor signaling RIPK1-mediated regulated necrosis Regulation of necroptotic cell death Downregulation of ERBB2 signaling Regulation of RUNX2 expression and activity Regulation of PTEN stability and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Metabolite levels ( 23823483) PR interval ( 30679814 30046033 32439900) QRS duration ( 31251759) Systolic blood pressure change trajectories ( 27980656) Testosterone levels ( 22675492)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098)
Interacting Genes		11 interacting genes: GOPC GSK3B KDM3A MAMSTR MRTFA MYOD1 SMAD2 SMAD3 SMARCA4 SRF STUB1	126 interacting genes: ABL1 ACD AHR AQP2 AR ATCAY ATXN3 BACE1 BAG1 BAG5 BCR BMPR1B CASP6 CCL28 CDK4 CDKN1A CFTR CIP2A CTBP2 CTNNB1 CYP2E1 CYP3A4 DAPK1 DAXX DNAAF4 DNAJB1 E2F8 EIF5A ERBB2 ERG ERN1 ESR1 FADD FBXO2 FBXO27 FOXP3 GHR GPR37 GUCY1A1 GUCY1A2 HIF1A HSF1 HSP90AA1 HSPA1A HSPA1B HSPA4 HSPA8 HSPA9 HSPB1 INSR JOSD1 JOSD2 KHDRBS1 LRRK1 LRRK2 MAP3K11 MAP3K2 MAP3K21 MAPK3 MAPT MCF2 MFHAS1 MITF MPP1 MST1R MYOCD NOS1 NQO1 NR3C1 OLFM3 PA2G4 PFN1 PLK1 POLB POT1 POU5F1 PPARG PPP3CA PRKACA PRKCZ PRKN PRMT1 PRMT5 PSMA3 PSMD4 PTEN RAF1 RGS17 RHBDF2 RUNX2 RUSC1 S100A2 S100P SIRT6 SMAD1 SMAD2 SMAD3 SMAD4 SMG5 SMURF1 SNPH SRC TAL1 TERF1 TGFBR1 TINF2 TPD52 TRAF6 TXN2 UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2L3 UBE2N UBE2Q1 UBE2V1 UBE2V2 UBE2W VCP XIAP
Entrez ID		93649	10273
HPRD ID		09362	06232
Ensembl ID		ENSG00000141052	ENSG00000103266
Uniprot IDs		Q8IZQ8	Q9UNE7
PDB IDs			4KBQ 6EFK 6NSV
Enriched GO Terms of Interacting Partners?
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