SIPA1L2 and ORC5

Data Source:
BioGRID (two hybrid)

		SIPA1L2	ORC5
Description		signal induced proliferation associated 1 like 2	origin recognition complex subunit 5
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytoplasm	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytosol
	Molecular Function	GTPase Activator Activity	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Biological_process Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Regulation Of DNA Replication
Pathways			E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Parkinson's disease ( 25064009 32201043 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post-traumatic stress disorder ( 24677629) PR interval ( 32439900) Reduced foot dorsiflexion strength in Charcot-Marie-Tooth disease type 1A ( 30706531) Schizophrenia ( 30285260) Smooth-surface caries ( 24556642)	Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)
Interacting Genes		5 interacting genes: AP3M1 DDX6 ORC5 TCEANC TGM2	30 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 H3-4 H4-16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2
Entrez ID		57568	5001
HPRD ID		15346	09086
Ensembl ID		ENSG00000116991	ENSG00000164815
Uniprot IDs		A0A6Q8PH54 Q9P2F8	A4D0P7 O43913 Q53FC8
PDB IDs			5UJ7 5UJM 7JPO 7JPP 7JPQ 7JPR 7JPS
Enriched GO Terms of Interacting Partners?
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