HECW2 and CBX1

Data Source:
BioGRID (pull down, affinity chromatography technology)

		HECW2	CBX1
Description		HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2	chromobox 1
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GO Annotations	Cellular Component	Cytoplasm Mitotic Spindle	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Site Of DNA Damage
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	HCMV Early Events
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Response to fenofibrate (LDL cholesterol levels) ( 27002377)	Body mass index ( 26426971 20935630) Generalized epilepsy ( 22949513)
Interacting Genes		8 interacting genes: CBX1 CBX3 CBX5 FZR1 TP73 UBE2D2 UBE2D3 UBE2L3	36 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 NSL1 PCNA PIM1 RB1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C
Entrez ID		57520	10951
HPRD ID		17099	05149
Ensembl ID		ENSG00000138411	ENSG00000108468
Uniprot IDs		A0A2R8Y6F3 Q9P2P5	P83916 Q6IBN6
PDB IDs		2LFE	2FMM 3F2U 3Q6S 5T1G 6D07 6D08
Enriched GO Terms of Interacting Partners?
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