CBX1 and HECW2

Data Source:
BioGRID (pull down, affinity chromatography technology)

		CBX1	HECW2
Description		chromobox 1	HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromosome, Telomeric Region Chromatin Heterochromatin Female Pronucleus Male Pronucleus Nucleus Nucleoplasm Pericentric Heterochromatin Spindle Chromocenter Site Of DNA Damage	Cytoplasm Mitotic Spindle
	Molecular Function	Chromatin Binding Protein Binding Enzyme Binding Identical Protein Binding Histone Methyltransferase Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Response To DNA Damage Stimulus Negative Regulation Of Transcription, DNA-templated	Protein Polyubiquitination Protein Ubiquitination Regulation Of Mitotic Metaphase/anaphase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Regulation Of Dendrite Morphogenesis Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		HCMV Early Events	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Body mass index ( 26426971 20935630) Generalized epilepsy ( 22949513)	Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		36 interacting genes: ABI3BP ARL5A ATXN7L2 BAHD1 BARD1 BRCA1 CBX3 CBX5 CHAF1A DNMT1 DNMT3A DNMT3B EMSY H1-4 H3-4 H3C1 H3C3 HECW2 HSPB1 KLF11 LNX1 LRIF1 NR2F6 NSL1 PCNA PIM1 RB1 RPL12 SP100 SUV39H1 TRIM24 TRIM28 UCHL1 VHL VTN ZNF280C	8 interacting genes: CBX1 CBX3 CBX5 FZR1 TP73 UBE2D2 UBE2D3 UBE2L3
Entrez ID		10951	57520
HPRD ID		05149	17099
Ensembl ID		ENSG00000108468	ENSG00000138411
Uniprot IDs		P83916 Q6IBN6	A0A2R8Y6F3 Q9P2P5
PDB IDs		2FMM 3F2U 3Q6S 5T1G 6D07 6D08	2LFE
Enriched GO Terms of Interacting Partners?
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