CNOT6 and CNOT8

Data Source:
HPRD (two hybrid)

		CNOT6	CNOT8
Description		CCR4-NOT transcription complex subunit 6	CCR4-NOT transcription complex subunit 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane CCR4-NOT Complex	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Nuclear Receptor Coactivator Activity Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of Transcription, DNA-templated Nuclear-transcribed MRNA Catabolic Process, No-go Decay RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Ovarian cancer ( 30557369)	High light scatter reticulocyte count ( 32888494)
Interacting Genes		4 interacting genes: CNOT4 CNOT7 CNOT8 PABPC1	9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2
Entrez ID		57472	9337
HPRD ID		12341	07225
Ensembl ID		ENSG00000113300	ENSG00000155508
Uniprot IDs			B7Z9U0 Q9UFF9
PDB IDs
Enriched GO Terms of Interacting Partners?
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