CNOT8 and CNOT2

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, proximity labelling technology)
HPRD (in vivo)

		CNOT8	CNOT2
Description		CCR4-NOT transcription complex subunit 8	CCR4-NOT transcription complex subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	P-body Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	RNA Polymerase II Transcription Corepressor Binding Transcription Coregulator Activity Poly(A)-specific Ribonuclease Activity Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Poly(A) Tail Shortening Trophectodermal Cell Differentiation Regulation Of Transcription By RNA Polymerase II Regulation Of Translation DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Gene Silencing By RNA Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Regulation Of Stem Cell Population Maintenance
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)	Amyotrophic lateral sclerosis (age of onset) ( 22959728) Diastolic blood pressure ( 27841878) Ovarian cancer ( 30557369) Triglyceride levels ( 32154731)
Interacting Genes		9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	26 interacting genes: ARMC5 BCL6 BEX1 C11orf1 C20orf85 CCHCR1 CNOT1 CNOT3 CNOT4 CNOT8 CSTF2 DDB1 GALNT10 GCSAM GPS1 GPS2 HSF2BP MTFR1L NCOR1 NCOR2 PRR35 PSMB4 RACK1 TBX2 TEKT3 ZFHX3
Entrez ID		9337	4848
HPRD ID		07225	05367
Ensembl ID		ENSG00000155508	ENSG00000111596
Uniprot IDs		B7Z9U0 Q9UFF9	A0A024RBD8 B2RDX7 B3KTL6 F8VUB4 F8VV52 Q9NZN8
PDB IDs			4C0D 4C0F 5FU6 5FU7
Enriched GO Terms of Interacting Partners?
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