CNOT8 and BTG1

Data Source:
BioGRID (two hybrid, two hybrid, pull down, two hybrid)
HPRD (in vitro)

		CNOT8	BTG1
Description		CCR4-NOT transcription complex subunit 8	BTG anti-proliferation factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol CCR4-NOT Complex CCR4-NOT Core Complex	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Metal Ion Binding	Transcription Coregulator Activity Protein Binding Enzyme Binding Kinase Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Transcription, DNA-templated DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Positive Regulation Of Cell Population Proliferation Negative Regulation Of Translation Gene Silencing By MiRNA Exonucleolytic Catabolism Of Deadenylated MRNA Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Regulation Of Transcription, DNA-templated Negative Regulation Of Cell Population Proliferation Cell Migration Negative Regulation Of Cell Growth Positive Regulation Of Endothelial Cell Differentiation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Fibroblast Apoptotic Process
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494)	Heart failure ( 20445134) Metabolite levels ( 23823483) Schizophrenia ( 28991256 29483656 30285260)
Interacting Genes		9 interacting genes: BTG1 BTG2 CNOT1 CNOT2 CNOT3 CNOT4 CNOT6 PRMT1 TOB2	16 interacting genes: CCNA2 CDKN2D CNOT7 CNOT8 FADD GRB2 HOXB9 NCK2 PRMT1 RARA RNF181 SKP2 THRA THRB TUBA1A XRCC6
Entrez ID		9337	694
HPRD ID		07225	15912
Ensembl ID		ENSG00000155508	ENSG00000133639
Uniprot IDs		B7Z9U0 Q9UFF9	P62324 Q6IBC8
PDB IDs
Enriched GO Terms of Interacting Partners?
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