PTGS1 and NCL

Data Source:
BioGRID (unspecified method, affinity chromatography technology)

		PTGS1	NCL
Description		prostaglandin-endoperoxide synthase 1	nucleolin
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Intracellular Membrane-bounded Organelle Extracellular Exosome	Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Heme Binding Metal Ion Binding Dioxygenase Activity	RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding
	Biological Process	Prostaglandin Biosynthetic Process Xenobiotic Metabolic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Cyclooxygenase Pathway Regulation Of Cell Population Proliferation Cellular Oxidant Detoxification	Angiogenesis Negative Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways		COX reactions Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Dihomo-gamma-linolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Antrafenine Antipyrine Tiaprofenic acid O-acetyl-L-serine Hyperforin (+)-2-(4-biphenyl)propionic acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic acid Beta-D-Glucose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Acetic Acid Salicyloyl-Amino-Ester P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic acid Arachidonic Acid Metamizole Lornoxicam Aceclofenac Nepafenac 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Triflusal Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Nitroaspirin Bufexamac Bendazac Acemetacin Medical Cannabis Nabiximols
Diseases
GWAS		Glomerular filtration rate in chronic kidney disease ( 26420894) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Height ( 31562340) Noise-induced hearing loss ( 26121033)
Interacting Genes		3 interacting genes: NCL NUCB1 PTGIS	57 interacting genes: ADAP1 ADAP2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 POLR1G PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689
Entrez ID		5742	4691
HPRD ID		07518	01245
Ensembl ID		ENSG00000095303	ENSG00000115053
Uniprot IDs		A0A087X296 P23219	B3KM80 P19338
PDB IDs		6Y3C	2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?
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