NCL and NPM1

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		NCL	NPM1
Description		nucleolin	nucleophosmin 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Chromosome Nucleolus Cell Cortex Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Ribonucleoprotein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex
	Molecular Function	RNA Binding Protein Binding Protein C-terminus Binding Telomeric DNA Binding Identical Protein Binding DNA Topoisomerase Binding MRNA 5'-UTR Binding	Core Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Tat Protein Binding Activating Transcription Factor Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding
	Biological Process	Angiogenesis Negative Regulation Of Translation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Repair Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II RRNA Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Cell Aging Protein Localization Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Cellular Response To UV Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol	Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs			Artenimol
Diseases
GWAS		Attention deficit hyperactivity disorder ( 23728934) Common carotid intima-media thickness in HIV negative individuals ( 29206233) Eating disorders (purging via substances) ( 23568457) Height ( 31562340) Noise-induced hearing loss ( 26121033)	Brain morphology (MOSTest) ( 32665545) Height ( 28552196) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		57 interacting genes: ADAP1 ADAP2 CD3E CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 DUX4 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R LINC01554 MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 POLR1G PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 S100A11 SREK1 SRPK2 SSB STAU1 SUMO2 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZFP41 ZNF689	62 interacting genes: ABCC1 ACY1 ALK APP ARF1 CACYBP CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CLK1 COX8A CSNK2A1 DUX4 EIF2AK2 ELF4 EP300 ERG ESR1 FBXW7 GADD45A GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 LINC01554 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SP1 SREK1 SUMO2 TCERG1 TFAP2A TP53 TRIM28 UBC UQCRH XPO1 YY1
Entrez ID		4691	4869
HPRD ID		01245	01246
Ensembl ID		ENSG00000115053	ENSG00000181163
Uniprot IDs		B3KM80 P19338	A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 P06748
PDB IDs		2FC8 2FC9 2KRR	2LLH 2P1B 2VXD 5EHD
Enriched GO Terms of Interacting Partners?
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