PTGS1 and PTGIS

Data Source:
BioGRID (fluorescent resonance energy transfer)

		PTGS1	PTGIS
Description		prostaglandin-endoperoxide synthase 1	prostaglandin I2 synthase
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Cytoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Intracellular Membrane-bounded Organelle Extracellular Exosome	Extracellular Space Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Caveola Integral Component Of Membrane
	Molecular Function	Peroxidase Activity Prostaglandin-endoperoxide Synthase Activity Protein Binding Heme Binding Metal Ion Binding Dioxygenase Activity	Monooxygenase Activity Iron Ion Binding Protein Binding Prostaglandin-I Synthase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Heme Binding Hydroperoxy Icosatetraenoate Dehydratase Activity
	Biological Process	Prostaglandin Biosynthetic Process Xenobiotic Metabolic Process Inflammatory Response Response To Oxidative Stress Regulation Of Blood Pressure Cyclooxygenase Pathway Regulation Of Cell Population Proliferation Cellular Oxidant Detoxification	Prostaglandin Biosynthetic Process Icosanoid Metabolic Process Cyclooxygenase Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity NAD Biosynthesis Via Nicotinamide Riboside Salvage Pathway Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Inflammatory Response Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Hypoxia Apoptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis
Pathways		COX reactions Synthesis of Prostaglandins (PG) and Thromboxanes (TX)	Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 24-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Nicotinamide salvaging Eicosanoids Sterols are 12-hydroxylated by CYP8B1 Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Drugs		Dihomo-gamma-linolenic acid Icosapent Mesalazine Acetaminophen Indomethacin Minoxidil Nabumetone Ketorolac Tenoxicam Tolmetin Piroxicam Fenoprofen Diclofenac Sulindac Diethylcarbamazine Flurbiprofen Etodolac Mefenamic acid Naproxen Sulfasalazine Phenylbutazone Meloxicam Carprofen Diflunisal Suprofen Salicylic acid Meclofenamic acid Acetylsalicylic acid Bromfenac Oxaprozin Ketoprofen Balsalazide Ibuprofen Lumiracoxib Magnesium salicylate Salsalate Choline magnesium trisalicylate Antrafenine Antipyrine Tiaprofenic acid O-acetyl-L-serine Hyperforin (+)-2-(4-biphenyl)propionic acid Protoporphyrin Ix Containing Co 2-Bromoacetyl Group Flufenamic acid Beta-D-Glucose Resveratrol (3-Chloro-4-Propoxy-Phenyl)-Acetic Acid Acetic Acid Salicyloyl-Amino-Ester P-(2'-Iodo-5'-Thenoyl)Hydrotropic Acid Flurbiprofen Methyl Ester Phenacetin Niflumic acid Arachidonic Acid Metamizole Lornoxicam Aceclofenac Nepafenac 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide 1-(4-IODOBENZOYL)-5-METHOXY-2-METHYL INDOLE-3-ACETIC ACID 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide Triflusal Cannabidiol Loxoprofen Dexibuprofen Dexketoprofen Droxicam Tolfenamic acid Propacetamol Talniflumate Phenyl salicylate Trolamine salicylate Menthyl salicylate Glycol salicylate Nitroaspirin Bufexamac Bendazac Acemetacin Medical Cannabis Nabiximols	Phenylbutazone Epoprostenol (5Z)-7-{(1R,4S,5R,6R)-6-[(1E)-1-Octen-1-yl]-2,3-diazabicyclo[2.2.1]hept-2-en-5-yl}-5-heptenoic acid
Diseases
GWAS		Glomerular filtration rate in chronic kidney disease ( 26420894) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		3 interacting genes: NCL NUCB1 PTGIS	3 interacting genes: APP PTGS1 PTGS2
Entrez ID		5742	5740
HPRD ID		07518	09046
Ensembl ID		ENSG00000095303	ENSG00000124212
Uniprot IDs		A0A087X296 P23219	Q16647
PDB IDs		6Y3C	2IAG 3B6H
Enriched GO Terms of Interacting Partners?
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