PTGDS and PTGER2

Data Source:
HPRD (in vivo)

		PTGDS	PTGER2
Description		prostaglandin D2 synthase	prostaglandin E receptor 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Small Molecule Binding	Prostaglandin E Receptor Activity
	Biological Process	Prostaglandin Biosynthetic Process Cyclooxygenase Pathway Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep	Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Prostaglandin E Stimulus Positive Regulation Of Gastric Mucosal Blood Circulation
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation	Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs		Vitamin A	Alprostadil Dinoprostone Misoprostol Gemeprost Limaprost
Diseases
GWAS		Beta-trace protein levels ( 23328707) Blood protein levels ( 29875488) Corneal structure ( 23291589)
Interacting Genes		22 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2	3 interacting genes: PTGDS PTGES PTGFR
Entrez ID		5730	5732
HPRD ID		08904	08905
Ensembl ID		ENSG00000107317	ENSG00000125384
Uniprot IDs		A0A024R8G3 P41222	P43116
PDB IDs		2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9
Enriched GO Terms of Interacting Partners?
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