RGL3 and RIT1

Data Source:
BioGRID (two hybrid)

		RGL3	RIT1
Description		ral guanine nucleotide dissociation stimulator like 3	Ras like without CAAX 1
Image		No pdb structure
GO Annotations	Cellular Component		Plasma Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	GTPase Activity Protein Binding Calmodulin Binding GTP Binding GDP Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity	Signal Transduction Ras Protein Signal Transduction
Pathways		RAF/MAP kinase cascade	Signalling to p38 via RIT and RIN
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878 27618447 27618448) Hypertension ( 31879980 27618447 27618448) Mean arterial pressure ( 27618448) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Pulse pressure ( 27841878 27618447) Systolic blood pressure ( 28135244 27841878 27618447 27618448 30578418)	Birth weight ( 31043758) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		6 interacting genes: FAM200A KLHL12 NRAS RIT1 RIT2 RRAS2	17 interacting genes: AFDN AP2A1 CUL3 IFRD1 KLHL12 LRIF1 LRRK2 LZTR1 PTN RALGDS RGL1 RGL3 RLF SMAD2 SMAD3 SMURF1 SRPK2
Entrez ID		57139	6016
HPRD ID		18844	10195
Ensembl ID		ENSG00000205517	ENSG00000143622
Uniprot IDs		A0A0A0MRX4 Q3MIN7	Q92963
PDB IDs			4KLZ
Enriched GO Terms of Interacting Partners?
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