CD177 and KCNIP3

Data Source:
HPRD (two hybrid)

		CD177	KCNIP3
Description		CD177 molecule	potassium voltage-gated channel interacting protein 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Lamellipodium Secretory Granule Membrane Specific Granule Membrane Plasma Membrane Raft Anchored Component Of Plasma Membrane Extracellular Exosome Tertiary Granule Membrane	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	Protease Binding Integrin Binding Protein Binding Calcium-dependent Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding
	Biological Process	Cell Adhesion Leukocyte Cell-cell Adhesion Blood Coagulation Regulation Of Endocytosis Positive Regulation Of Superoxide Anion Generation Protein Localization To Cell Surface Neutrophil Degranulation Positive Regulation Of Neutrophil Degranulation Innate Immune Response Cell-cell Junction Maintenance Leukocyte Migration Neutrophil Extravasation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Neutrophil Migration Regulation Of Integrin-mediated Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		Common Pathway of Fibrin Clot Formation Cell surface interactions at the vascular wall Neutrophil degranulation	Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		3 interacting genes: EWSR1 KCNIP3 SHBG	26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16
Entrez ID		57126	30818
HPRD ID		01222	05232
Ensembl ID		ENSG00000204936	ENSG00000115041
Uniprot IDs		A0A087WVM2 Q8N6Q3	A0A024RE22 Q9Y2W7
PDB IDs			2E6W
Enriched GO Terms of Interacting Partners?
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