KCNIP3 and SOD3

Data Source:
BioGRID (two hybrid)

		KCNIP3	SOD3
Description		potassium voltage-gated channel interacting protein 3	superoxide dismutase 3
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus	Extracellular Region Extracellular Space Nucleus Golgi Lumen Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding	Superoxide Dismutase Activity Copper Ion Binding Protein Binding Heparin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Response To Hypoxia Removal Of Superoxide Radicals Cellular Response To Oxidative Stress Response To Copper Ion
Pathways		Phase 1 - inactivation of fast Na+ channels	Detoxification of Reactive Oxygen Species Detoxification of Reactive Oxygen Species
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Blood protein levels ( 30072576 29875488) Major depressive disorder ( 23377640)
Interacting Genes		26 interacting genes: ASPH C1QTNF2 CALM2 CASP3 CD177 CDSN CLN3 CREB1 CREM CTBP2 GOLGA7 GRK2 GRK6 IGF1R IGLV3-25 IL6ST KHDC4 MAVS PCBD2 PPP3CA PSEN1 PSEN2 SOD3 SRL TARBP2 ZG16	9 interacting genes: ASPH FBLN5 GOLM2 KCNIP1 KCNIP3 SGTA SGTB UBQLN1 UBQLN2
Entrez ID		30818	6649
HPRD ID		05232	01708
Ensembl ID		ENSG00000115041	ENSG00000109610
Uniprot IDs		A0A024RE22 Q9Y2W7	A0A140VJU8 P08294
PDB IDs		2E6W	2JLP
Enriched GO Terms of Interacting Partners?
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