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KCNIP3 and MAVS
Data Source:
BioGRID
(two hybrid)
KCNIP3
MAVS
Description
potassium voltage-gated channel interacting protein 3
mitochondrial antiviral signaling protein
Image
GO Annotations
Cellular Component
Nucleus
Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Voltage-gated Potassium Channel Complex
Dendrite
Protein-DNA Complex
Axon Terminus
Mitochondrion
Mitochondrial Outer Membrane
Peroxisomal Membrane
Integral Component Of Membrane
Mitochondrial Membrane
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Voltage-gated Ion Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein Binding
Potassium Channel Regulator Activity
Ion Channel Binding
Protein Binding
Protein Kinase Binding
Signaling Adaptor Activity
CARD Domain Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Protein Transport
Apoptotic Process
Signal Transduction
Cardiac Conduction
Potassium Ion Transmembrane Transport
Protein Localization To Plasma Membrane
Regulation Of Potassium Ion Transmembrane Transport
Positive Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Positive Regulation Of Myeloid Dendritic Cell Cytokine Production
Signal Transduction
Viral Process
Negative Regulation Of Type I Interferon Production
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Viral Genome Replication
Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of DNA-binding Transcription Factor Activity
Defense Response To Virus
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Response To Cytokine Stimulus
Cellular Response To Exogenous DsRNA
Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production
Positive Regulation Of IP-10 Production
Regulation Of Peroxisome Organization
Pathways
Phase 1 - inactivation of fast Na+ channels
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Ovarian tumor domain proteases
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
TRAF6 mediated NF-kB activation
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Negative regulators of DDX58/IFIH1 signaling
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Platelet distribution width (
32888494
)
Interacting Genes
26 interacting genes:
ASPH
C1QTNF2
CALM2
CASP3
CD177
CDSN
CLN3
CREB1
CREM
CTBP2
GOLGA7
GRK2
GRK6
IGF1R
IGLV3-25
IL6ST
KHDC4
MAVS
PCBD2
PPP3CA
PSEN1
PSEN2
SOD3
SRL
TARBP2
ZG16
20 interacting genes:
ABL1
DDX3X
DDX58
IKBKB
IRF3
IRF5
IRF7
KCNIP3
MAP3K7
OAS3
OTUD4
RIPK2
RNF34
RNF5
SMURF2
STAT1
TBK1
TICAM1
TRAF6
UBE4A
Entrez ID
30818
57506
HPRD ID
05232
13847
Ensembl ID
ENSG00000115041
ENSG00000088888
Uniprot IDs
A0A024RE22
Q9Y2W7
Q7Z434
PDB IDs
2E6W
2MS7
2MS8
2VGQ
3J6C
3J6J
3RC5
4P4H
4Z8M
5JEK
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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