CYSLTR2 and RNF144A

Data Source:
BioGRID (two hybrid)

		CYSLTR2	RNF144A
Description		cysteinyl leukotriene receptor 2	ring finger protein 144A
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Plasma Membrane Integral Component Of Plasma Membrane	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Cysteinyl Leukotriene Receptor Activity Leukotriene Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity	Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Immune Response G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Pathways		Glucagon signaling in metabolic regulation Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production LTC4-CYSLTR mediated IL4 production	E3 ubiquitin ligases ubiquitinate target proteins
Drugs		Nedocromil Leukotriene C4 Leukotriene D4
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)	Allergic rhinitis ( 30013184) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)
Interacting Genes		19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE	27 interacting genes: CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR MFSD5 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC7A1 TMEM31 UBC UBE2D1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A
Entrez ID		57105	9781
HPRD ID		09293	11510
Ensembl ID		ENSG00000152207	ENSG00000151692
Uniprot IDs		A4ZKH2 Q5KU17 Q9NS75	P50876
PDB IDs			1WIM
Enriched GO Terms of Interacting Partners?
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