RNF144A and RFT1

Data Source:
BioGRID (two hybrid)

		RNF144A	RFT1
Description		ring finger protein 144A	RFT1 homolog
Image			No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Dolichol-linked Oligosaccharide Biosynthetic Process Carbohydrate Transport Glycolipid Translocation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective RFT1 causes RFT1-CDG (CDG-1n)
Drugs
Diseases			Congenital disorders of glycosylation (CDG) type I
GWAS		Allergic rhinitis ( 30013184) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Esophageal adenocarcinoma x smoking interaction ( 29551738) Intracranial aneurysm ( 30823506) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Manic episodes in bipolar disorder ( 26297903) Response to antipsychotic treatment ( 20195266)	Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Crohn's disease ( 28067908) Feeling worry ( 29500382) Height ( 23563607 31562340) High density lipoprotein cholesterol levels ( 31928498) Hip circumference adjusted for BMI ( 25673412) Immune reponse to smallpox (secreted IL-2) ( 22610502) Schizophrenia ( 23974872) Serum uric acid levels ( 30993211 29403010) Type 2 diabetes ( 30297969)
Interacting Genes		27 interacting genes: CYSLTR2 DGAT2L6 E2F1 E2F2 E2F3 E2F4 EGFR MFSD5 PAQR6 PARP1 RFT1 SEC22A SGTA SGTB SLC7A1 TMEM31 UBC UBE2D1 UBE2H UBE2K UBE2L3 UBE2L6 UBE2V1 UBE2V2 USP21 USP32 YIF1A	12 interacting genes: AQP6 BEST2 CNR2 CREB3L1 ERGIC3 MUC1 NEDD4 PSMA3 RNF144A TMX2 TNS2 TSPAN12
Entrez ID		9781	91869
HPRD ID		11510	15239
Ensembl ID		ENSG00000151692	ENSG00000163933
Uniprot IDs		P50876	Q96AA3
PDB IDs		1WIM
Enriched GO Terms of Interacting Partners?
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