CYSLTR2 and NCKIPSD

Data Source:
BioGRID (two hybrid)

		CYSLTR2	NCKIPSD
Description		cysteinyl leukotriene receptor 2	NCK interacting protein with SH3 domain
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Plasma Membrane Integral Component Of Plasma Membrane	Cytosol Intermediate Filament COP9 Signalosome
	Molecular Function	Cysteinyl Leukotriene Receptor Activity Leukotriene Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity	Protein Binding Cytoskeletal Protein Binding SH3 Domain Binding
	Biological Process	Immune Response G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway	Cytoskeleton Organization Positive Regulation Of Neuron Projection Development Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Pathways		Glucagon signaling in metabolic regulation Leukotriene receptors G alpha (q) signalling events G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production LTC4-CYSLTR mediated IL4 production	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs		Nedocromil Leukotriene C4 Leukotriene D4
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Post bronchodilator FEV1/FVC ratio ( 26634245) Response to inhaled corticosteroid treatment in asthma (change in FEV1) ( 24792382) Systemic juvenile idiopathic arthritis ( 27927641)	Anorexia nervosa ( 31308545) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Intelligence (MTAG) ( 29326435) Parkinson's disease ( 28892059) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)
Interacting Genes		19 interacting genes: ATP5MC2 DBI ENO1 GNAS GRIK1 HSP90B1 KRTAP1-1 LNX1 MTUS2 NCKIPSD PCDH9 PCMT1 RNASEK RNF144A RTN4 SVOP TTC19 YIPF6 YWHAE	41 interacting genes: ABI2 ARHGEF7 BAIAP2 CCDC187 CPNE2 CYSLTR2 DIAPH2 DIAPH3 DLG4 DMRTB1 ENKD1 FASLG GAS7 GRB2 HSPB1 ITGB1 KHDRBS1 LGALS4 MAPK3 MED25 NCK1 NCK2 PIN1 PKP2 POLR3C PRPF31 PSMD9 PSORS1C2 RBM22 RBP7 RXFP3 SNRPC SORBS3 STAC TSEN54 VEZF1 WAS WASL YWHAG ZBTB47 ZC2HC1C
Entrez ID		57105	51517
HPRD ID		09293	09450
Ensembl ID		ENSG00000152207	ENSG00000213672
Uniprot IDs		A4ZKH2 Q5KU17 Q9NS75	Q9NZQ3
PDB IDs			6DEC 6DED 6DEE
Enriched GO Terms of Interacting Partners?
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