ATXN7L3 and UCHL3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ATXN7L3	UCHL3
Description		ataxin 7 like 3	ubiquitin C-terminal hydrolase L3
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GO Annotations	Cellular Component	SAGA Complex Nucleus DUBm Complex	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone Monoubiquitination Histone Deubiquitination Positive Regulation Of Transcription, DNA-templated	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Phosphopantetheinylation Protein Catabolic Process Post-translational Protein Modification
Pathways		HATs acetylate histones	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Height ( 31562340)	Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: APP ENY2 H2AC20 H2BC21 PICK1 SECISBP2 SERTAD1 UBC UCHL3 USP22 USP6	20 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBE2S USP15 USP21 USP28 XRCC5
Entrez ID		56970	7347
HPRD ID		12507	04367
Ensembl ID		ENSG00000087152	ENSG00000118939
Uniprot IDs		Q14CW9	A0A087WTB8 A0A140VJZ4 P15374
PDB IDs		2KKT	1UCH 1XD3 6ISU 6QML
Enriched GO Terms of Interacting Partners?
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