PRTFDC1 and TCL1A

Data Source:
BioGRID (two hybrid)

		PRTFDC1	TCL1A
Description		phosphoribosyl transferase domain containing 1	TCL1 family AKT coactivator A
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GO Annotations	Cellular Component		Nucleoplasm Endoplasmic Reticulum Cytosol Protein-containing Complex
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Hypoxanthine Phosphoribosyltransferase Activity Protein Binding Protein Homodimerization Activity	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	Purine Ribonucleoside Salvage Guanine Salvage GMP Catabolic Process	Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Positive Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Apoptotic Process Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132) Eosinophil counts ( 32888494) Granulocyte count ( 27863252) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 29617998) Lymphocyte counts ( 32888494 27863252) Metabolite levels (Pyroglutamine) ( 23934736) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Obesity-related traits ( 23251661) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Post-traumatic stress disorder ( 25456346) Red cell distribution width ( 32888494 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Adverse response to aromatase inhibitors ( 20876420) Mosaic loss of chromosome Y ( 27064253) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Plateletcrit ( 32888494) Refractive error ( 32231278)
Interacting Genes		19 interacting genes: CNRIP1 DTNB EEF2KMT EPM2AIP1 EWSR1 FLAD1 GNPDA1 HPRT1 LGALS9B LNX1 MCMBP NIF3L1 NTAQ1 SIK1B SPG21 STAT5A TCL1A TMEM14B VWA5A	38 interacting genes: AKT1 AKT2 AKT3 ATM CADPS CALCOCO2 CARD9 CASP8AP2 CCDC13 CEP55 DDIT4L DNMT3A FLACC1 GOLGA2 H2AW INCA1 LNX1 LNX2 LSM3 NFKBIA NFKBID NIF3L1 NTAQ1 PPP1R13B PRTFDC1 REL TAX1BP1 TCF4 TEPSIN TNKS TP53BP2 TRAF1 TRAF2 TRMT61A TTC33 TXLNA TXLNB WDR47
Entrez ID		56952	8115
HPRD ID		17917	01744
Ensembl ID		ENSG00000099256	ENSG00000100721
Uniprot IDs		Q9NRG1	A0A024R6G5 P56279
PDB IDs		2JBH	1JSG
Enriched GO Terms of Interacting Partners?
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