PSG5 and TIE1

Data Source:
BioGRID (pull down)

		PSG5	TIE1
Description		pregnancy specific beta-1-glycoprotein 5	tyrosine kinase with immunoglobulin like and EGF like domains 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region	Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	Female Pregnancy	Angiogenesis Vasculogenesis In Utero Embryonic Development Regulation Of Endothelial Cell Proliferation Aortic Valve Morphogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Mesoderm Development Negative Regulation Of Angiogenesis Peptidyl-tyrosine Phosphorylation Negative Regulation Of Cell Migration Response To Retinoic Acid Positive Regulation Of Kinase Activity Plasma Membrane Fusion Positive Regulation Of Angiogenesis Tissue Remodeling Lymphatic Endothelial Cell Differentiation Branching Involved In Lymph Vessel Morphogenesis Regulation Of Extracellular Matrix Assembly
Pathways		Cell surface interactions at the vascular wall
Drugs		Alitretinoin	Fostamatinib
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Hemoglobin levels ( 32327693) Platelet count ( 32888494) Red blood cell count ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		3 interacting genes: NLGN3 PRPF40A TIE1	13 interacting genes: ANGPT1 ANGPT4 KRT40 KRTAP10-8 MDFI MTMR14 PIK3R1 PSG5 PTPN11 RBPMS TEK TRIP6 ZRANB1
Entrez ID		5673	7075
HPRD ID		08894	02572
Ensembl ID		ENSG00000204941	ENSG00000066056
Uniprot IDs		A0A024R0S1 Q15238	B4DTW8 P35590
PDB IDs			5N06
Enriched GO Terms of Interacting Partners?
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