TWNK and AKTIP

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TWNK	AKTIP
Description		twinkle mtDNA helicase	AKT interacting protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Mitochondrial Nucleoid	Nucleus Cytosol Plasma Membrane HOPS Complex FHF Complex
	Molecular Function	Protease Binding DNA Helicase Activity Single-stranded DNA Binding ATP Binding Identical Protein Binding 5'-3' DNA Helicase Activity	Protein Binding Ubiquitin-like Protein Transferase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitochondrial DNA Replication DNA Unwinding Involved In DNA Replication Mitochondrial Transcription Mitochondrion Organization Protein Hexamerization Cellular Response To Glucose Stimulus	Protein Polyubiquitination Positive Regulation Of Protein Phosphorylation Apoptotic Process Cellular Response To DNA Damage Stimulus Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Protein Phosphopantetheinylation Positive Regulation Of Protein Binding Early Endosome To Late Endosome Transport
Pathways		Transcriptional activation of mitochondrial biogenesis
Drugs
Diseases		Mitochondrial DNA depletion syndrome (MDS)
GWAS			Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Depressive symptoms (SSRI exposure interaction) ( 25649181) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Hip circumference adjusted for BMI ( 25673412) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		2 interacting genes: AKTIP SMAD9	34 interacting genes: ACTN2 AKT1 ASS1 CEP126 CTBP2 DMXL2 DZIP3 EXOC7 FHIP1B GTF3C1 HOOK1 HOOK2 HOOK3 IMMT IPO7 LMNA MAP3K7 MARCHF5 MATR3 NEB PDE4DIP PDPK1 POLA2 RASGRF2 RPA1 TRIM23 TRIM32 TRIM41 TWNK UPF2 UTP14A VPS16 VPS18 VPS41
Entrez ID		56652	64400
HPRD ID		05830	07467
Ensembl ID		ENSG00000107815	ENSG00000166971
Uniprot IDs		A0A2R8Y4V4 A0A2R8Y746 E5KSY5 Q96RR1 Q9H6V3	A0A024R6S6 A0A024R6T5 Q9H8T0
PDB IDs
Enriched GO Terms of Interacting Partners?
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