PRPS1 and PRPSAP1

Data Source:
HPRD (in vivo, in vitro)

		PRPS1	PRPSAP1
Description		phosphoribosyl pyrophosphate synthetase 1	phosphoribosyl pyrophosphate synthetase associated protein 1
Image
GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol	Ribose Phosphate Diphosphokinase Complex Cytoplasm
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Protein Homodimerization Activity	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Enzyme Inhibitor Activity Protein Binding Identical Protein Binding
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Nucleoside Metabolic Process Ribonucleoside Monophosphate Biosynthetic Process Phosphorylation Urate Biosynthetic Process Hypoxanthine Biosynthetic Process	5-phosphoribose 1-diphosphate Biosynthetic Process Nucleobase-containing Compound Metabolic Process Purine Nucleotide Biosynthetic Process Negative Regulation Of Catalytic Activity
Pathways		5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Arts syndrome Phosphoribosylpyrophosphate synthetase I superactivity
GWAS			High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) High-grade serous ovarian cancer ( 31469419) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Urate levels ( 23263486)
Interacting Genes		5 interacting genes: GORASP2 PRPSAP1 PRPSAP2 SPG21 SUMO4	9 interacting genes: CAPN7 DDX19B MAGOHB MAPK1 PLEKHF2 PRPS1 PRPS2 PRPSAP2 UBE2I
Entrez ID		5631	5635
HPRD ID		02413	03151
Ensembl ID		ENSG00000147224	ENSG00000161542
Uniprot IDs		B7ZB02 P60891	B4DP31 Q14558
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U	2C4K
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?