PRPS1 and SUMO4

Data Source:
HPRD (in vivo)

		PRPS1	SUMO4
Description		phosphoribosyl pyrophosphate synthetase 1	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Ribose Phosphate Diphosphokinase Complex Cytoplasm Cytosol	Nucleus SUMO Ligase Complex
	Molecular Function	Magnesium Ion Binding Ribose Phosphate Diphosphokinase Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Protein Homodimerization Activity	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	5-phosphoribose 1-diphosphate Biosynthetic Process Purine Nucleobase Metabolic Process Purine Nucleotide Biosynthetic Process Pyrimidine Nucleotide Biosynthetic Process Nervous System Development Nucleoside Metabolic Process Ribonucleoside Monophosphate Biosynthetic Process Phosphorylation Urate Biosynthetic Process Hypoxanthine Biosynthetic Process	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		5-Phosphoribose 1-diphosphate biosynthesis
Drugs
Diseases		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy Arts syndrome Phosphoribosylpyrophosphate synthetase I superactivity
GWAS			Dupuytren's disease ( 28886342)
Interacting Genes		5 interacting genes: GORASP2 PRPSAP1 PRPSAP2 SPG21 SUMO4	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		5631	387082
HPRD ID		02413	10584
Ensembl ID		ENSG00000147224	ENSG00000177688
Uniprot IDs		B7ZB02 P60891	Q6EEV6
PDB IDs		2H06 2H07 2H08 2HCR 3EFH 3S5J 4F8E 4LYG 4LZN 4LZO 4M0P 4M0U
Enriched GO Terms of Interacting Partners?
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