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PRKDC and H1-2
Data Source:
BioGRID
(affinity chromatography technology, affinity chromatography technology, pull down)
PRKDC
H1-2
Description
protein kinase, DNA-activated, catalytic subunit
H1.2 linker histone, cluster member
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
Transcription Regulator Complex
Nucleolus
Cytosol
DNA-dependent Protein Kinase-DNA Ligase 4 Complex
Membrane
Small-subunit Processome
Protein-containing Complex
Protein-DNA Complex
Nonhomologous End Joining Complex
Nucleosome
Euchromatin
Nucleus
Molecular Function
Double-stranded DNA Binding
RNA Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
DNA-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Enzyme Binding
Protein Domain Specific Binding
U3 SnoRNA Binding
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Double-stranded DNA Binding
RNA Binding
Protein Binding
Chromatin DNA Binding
Nucleosomal DNA Binding
Biological Process
Maturation Of 5.8S RRNA
Telomere Maintenance
Somitogenesis
Negative Regulation Of Protein Phosphorylation
Activation Of Innate Immune Response
B Cell Lineage Commitment
Pro-B Cell Differentiation
T Cell Lineage Commitment
Negative Regulation Of Immunoglobulin Production
Double-strand Break Repair
Double-strand Break Repair Via Nonhomologous End Joining
Cellular Protein Modification Process
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Brain Development
Heart Development
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Response To Activity
Telomere Capping
Protein Ubiquitination
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Protein Destabilization
Positive Regulation Of Type I Interferon Production
Cellular Response To Insulin Stimulus
T Cell Differentiation In Thymus
Immunoglobulin V(D)J Recombination
T Cell Receptor V(D)J Recombination
Small-subunit Processome Assembly
Ectopic Germ Cell Programmed Cell Death
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Innate Immune Response
Positive Regulation Of Lymphocyte Differentiation
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Translation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fibroblast Proliferation
Rhythmic Process
Spleen Development
Thymus Development
Positive Regulation Of Developmental Growth
Regulation Of Smooth Muscle Cell Proliferation
Regulation Of Epithelial Cell Proliferation
Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint
Double-strand Break Repair Via Alternative Nonhomologous End Joining
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Platelet Formation
Negative Regulation Of Cellular Senescence
Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Negative Regulation Of Response To Gamma Radiation
Nucleosome Assembly
Nucleosome Positioning
Chromosome Condensation
Negative Regulation Of Chromatin Silencing
Negative Regulation Of DNA Recombination
Pathways
Cytosolic sensors of pathogen-associated DNA
IRF3-mediated induction of type I IFN
Nonhomologous End-Joining (NHEJ)
E3 ubiquitin ligases ubiquitinate target proteins
Apoptosis induced DNA fragmentation
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Caffeine
SF1126
Diseases
GWAS
Adult body size (
32376654
)
Hemoglobin (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
91 interacting genes:
ABL1
AICDA
AKT1
AKT2
AP1B1
ATM
ATRIP
BRCA1
C1D
CASP3
CCNB1
CHEK1
CHEK2
CHUK
CIB1
CLK1
CTDP1
DCAF1
DCLRE1C
DUX4
E4F1
EIF2S2
EIF4EBP1
EP300
ERG
FH
GSK3A
GSK3B
GZMB
H1-1
H1-2
H2AX
HDAC3
HMGB1
HMGB2
HNRNPA1
HNRNPC
HOXC4
HSF1
HSP90AA1
IKBKB
ILF2
JUN
KAT2A
LIG4
LYN
MAPK8
MBP
MKNK1
MRE11
MTNR1B
NBN
NCF1
NCF2
NCF4
NCOA6
NR3C1
PARP1
PCNA
PDX1
PGR
POU2F1
PPP6C
PPP6R1
PPP6R3
PRKCD
PTEN
RAD17
RASSF1
RBBP8
RPA1
RPA2
SGO1
SP1
SRF
SUMO2
THRA
THRB
TOP1
TP53
TREX1
UBE2I
USF1
WRN
XPA
XRCC4
XRCC5
XRCC6
YWHAG
YWHAQ
ZBTB7A
30 interacting genes:
AEBP2
APP
ASXL1
CDC73
CSNK2A2
CTNNB1
CTR9
CUL4A
DDB1
F10
IL7R
IRAK4
KPNA7
KPNB1
LEO1
NASP
NCL
NSD1
PAF1
PARP1
POLR2A
PRKCA
PRKDC
PUF60
RBM39
SNCA
VHL
WDR12
WDR5
YBX1
Entrez ID
5591
3006
HPRD ID
02941
07514
Ensembl ID
ENSG00000253729
ENSG00000187837
Uniprot IDs
P78527
P16403
PDB IDs
5LUQ
5W1R
5Y3R
6ZFP
6ZH2
6ZH4
6ZH6
6ZH8
6ZHA
6ZHE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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