H1-2 and CTR9

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		H1-2	CTR9
Description		H1.2 linker histone, cluster member	CTR9 homolog, Paf1/RNA polymerase II complex component
Image		No pdb structure
GO Annotations	Cellular Component	Nucleosome Euchromatin Nucleus	Nucleoplasm Cdc73/Paf1 Complex Nuclear Speck Transcriptionally Active Chromatin
	Molecular Function	Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	RNA Polymerase II Complex Binding Protein Binding SH2 Domain Binding
	Biological Process	Nucleosome Assembly Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Blastocyst Growth Blastocyst Hatching Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Receptor Signaling Pathway Via JAK-STAT Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Histone H2B Ubiquitination Negative Regulation Of Myeloid Cell Differentiation Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K4 Methylation Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Histone H3-K4 Trimethylation Negative Regulation Of MRNA Polyadenylation Regulation Of Genetic Imprinting Positive Regulation Of Histone H3-K79 Methylation Positive Regulation Of Histone H2B Ubiquitination
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases
GWAS			Migraine ( 27182965)
Interacting Genes		30 interacting genes: AEBP2 APP ASXL1 CDC73 CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 IL7R IRAK4 KPNA7 KPNB1 LEO1 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 RBM39 SNCA VHL WDR12 WDR5 YBX1	7 interacting genes: BLK CNTNAP2 H1-2 SMAD9 SOX4 SUMO2 TCEA1
Entrez ID		3006	9646
HPRD ID		07514	06717
Ensembl ID		ENSG00000187837	ENSG00000198730
Uniprot IDs		P16403	Q6PD62
PDB IDs			5ZYQ 6GMH 6TED
Enriched GO Terms of Interacting Partners?
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