ASH1L and OXTR

Data Source:
BioGRID (two hybrid)

		ASH1L	OXTR
Description		ASH1 like histone lysine methyltransferase	oxytocin receptor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Golgi Apparatus Bicellular Tight Junction	Plasma Membrane Integral Component Of Plasma Membrane Microvillus Adherens Junction Apical Plasma Membrane
	Molecular Function	DNA Binding Chromatin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K36 Specific)	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity Peptide Hormone Binding Peptide Binding
	Biological Process	Skeletal System Development Negative Regulation Of Acute Inflammatory Response Single Fertilization Post-embryonic Development Flagellated Sperm Motility Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Decidualization Histone H3-K9 Methylation Histone H3-K4 Methylation Uterus Morphogenesis Histone H3-K36 Dimethylation Tarsal Gland Development Uterine Gland Development	Suckling Behavior Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Muscle Contraction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Lactation Memory Positive Regulation Of Norepinephrine Secretion Telencephalon Development Sleep Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Anoxia Response To Cytokine Social Behavior Response To Cocaine Response To Drug Maternal Behavior Sperm Ejaculation Eating Behavior Response To Peptide Hormone Estrous Cycle Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Digestive Tract Development Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Parturition Positive Regulation Of Penile Erection Negative Regulation Of Gastric Acid Secretion ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis
Pathways		PKMTs methylate histone lysines	Vasopressin-like receptors G alpha (q) signalling events
Drugs			Oxytocin Carbetocin Atosiban Relcovaptan
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 31065058) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Nickel levels ( 26025379) Non-cardia gastric cancer ( 26701879) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Caudate activity during reward ( 28927378) Chronotype ( 30696823) Depression and alcohol dependence ( 22064162) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598) Morning person ( 30696823)
Interacting Genes		3 interacting genes: H3C1 OXTR SMAD7	18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3
Entrez ID		55870	5021
HPRD ID		06416	01328
Ensembl ID		ENSG00000116539	ENSG00000180914
Uniprot IDs		Q9NR48	B2R9L7 P30559
PDB IDs		3MQM 3OPE 4YNM 4YNP 4YPA 4YPE 4YPU 6AGO 6INE	6TPK
Enriched GO Terms of Interacting Partners?
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