OXTR and ASH1L

Data Source:
BioGRID (two hybrid)

		OXTR	ASH1L
Description		oxytocin receptor	ASH1 like histone lysine methyltransferase
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Microvillus Adherens Junction Apical Plasma Membrane	Nucleus Nucleoplasm Chromosome Golgi Apparatus Bicellular Tight Junction
	Molecular Function	G Protein-coupled Receptor Activity Oxytocin Receptor Activity Vasopressin Receptor Activity Peptide Hormone Binding Peptide Binding	DNA Binding Chromatin Binding Histone Methyltransferase Activity (H3-K4 Specific) Metal Ion Binding Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K36 Specific)
	Biological Process	Suckling Behavior Response To Amphetamine Regulation Of Systemic Arterial Blood Pressure By Vasopressin Muscle Contraction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Lactation Memory Positive Regulation Of Norepinephrine Secretion Telencephalon Development Sleep Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Anoxia Response To Cytokine Social Behavior Response To Cocaine Response To Drug Maternal Behavior Sperm Ejaculation Eating Behavior Response To Peptide Hormone Estrous Cycle Positive Regulation Of Blood Pressure Positive Regulation Of Vasoconstriction Digestive Tract Development Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Maternal Process Involved In Parturition Positive Regulation Of Penile Erection Negative Regulation Of Gastric Acid Secretion ERK1 And ERK2 Cascade Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis	Skeletal System Development Negative Regulation Of Acute Inflammatory Response Single Fertilization Post-embryonic Development Flagellated Sperm Motility Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Decidualization Histone H3-K9 Methylation Histone H3-K4 Methylation Uterus Morphogenesis Histone H3-K36 Dimethylation Tarsal Gland Development Uterine Gland Development
Pathways		Vasopressin-like receptors G alpha (q) signalling events	PKMTs methylate histone lysines
Drugs		Oxytocin Carbetocin Atosiban Relcovaptan
Diseases
GWAS		Caudate activity during reward ( 28927378) Chronotype ( 30696823) Depression and alcohol dependence ( 22064162) Liver fibrosis severity in HIV/hepatitis C co-infection ( 27339598) Morning person ( 30696823)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Dementia with Lewy bodies ( 31065058) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908) Nickel levels ( 26025379) Non-cardia gastric cancer ( 26701879) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: ALAS1 ARRB2 ASH1L AVP CD81 CYFIP2 EMC10 FSCN1 GPRASP1 LCNL1 MVB12A OXT PSMA7 SIRT2 THOC5 TMEM161A TSPAN7 YIPF3	3 interacting genes: H3C1 OXTR SMAD7
Entrez ID		5021	55870
HPRD ID		01328	06416
Ensembl ID		ENSG00000180914	ENSG00000116539
Uniprot IDs		B2R9L7 P30559	Q9NR48
PDB IDs		6TPK	3MQM 3OPE 4YNM 4YNP 4YPA 4YPE 4YPU 6AGO 6INE
Enriched GO Terms of Interacting Partners?
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