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PRKCI and PARD6A
Data Source:
HPRD
(in vitro, two hybrid)
PRKCI
PARD6A
Description
protein kinase C iota
par-6 family cell polarity regulator alpha
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Bicellular Tight Junction
Microtubule Cytoskeleton
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Ruffle
Nucleus
Centrosome
Cytosol
Plasma Membrane
Bicellular Tight Junction
Cell Cortex
Apical Plasma Membrane
Centriolar Satellite
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Phospholipid Binding
Metal Ion Binding
Protein Kinase C Binding
Protein Binding
Transcription Factor Binding
GTP-dependent Protein Binding
Small GTPase Binding
Biological Process
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Peptidyl-serine Phosphorylation
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Response To Interleukin-1
Bicellular Tight Junction Assembly
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Protein Phosphorylation
Centrosome Cycle
Establishment Or Maintenance Of Cell Polarity
Transforming Growth Factor Beta Receptor Signaling Pathway
Viral Process
Cell-cell Junction Maintenance
Positive Regulation Of Protein Secretion
Cell Division
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cellular Localization
Bicellular Tight Junction Assembly
Positive Regulation Of Protein Localization To Centrosome
Pathways
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Tight junction interactions
Asymmetric localization of PCP proteins
Drugs
Tamoxifen
Bisindolylmaleimide I
Fostamatinib
Diseases
GWAS
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
31511532
)
Obesity-related traits (
23251661
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
52 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
RPA2
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
26 interacting genes:
APP
CDC42
CDH5
CRB3
DVL2
ECT2
GLS
MAP2K5
MARK2
MARK4
PARD3
PARD6B
PLCB1
PLCB3
PRKCG
PRKCH
PRKCI
PRKCZ
PTPN21
RAC1
RHOQ
TCP10L3
TGFBR1
WDR83
YWHAH
YWHAZ
Entrez ID
5584
50855
HPRD ID
02105
06316
Ensembl ID
ENSG00000163558
ENSG00000102981
Uniprot IDs
P41743
Q9NPB6
PDB IDs
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
1WMH
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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