PARD6A and CRB3

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		PARD6A	CRB3
Description		par-6 family cell polarity regulator alpha	crumbs cell polarity complex component 3
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GO Annotations	Cellular Component	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite	Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Apical Plasma Membrane Cell Junction Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding GTP-dependent Protein Binding Small GTPase Binding	Protein Binding SH3 Domain Binding Protein Domain Specific Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cellular Localization Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization To Centrosome	Bicellular Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Cell Junction Assembly
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins	Tight junction interactions
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		26 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	28 interacting genes: ANKRD46 BCL2L13 BET1 FUNDC2 HMOX1 HMOX2 NDUFA3 PALS1 PARD6A PATJ PLLP PLP2 PSENEN PSMA3 RABAC1 SERF1A SERF1B SERP1 SLC39A9 STX5 TECR TMEM222 TREX1 UBIAD1 VAMP1 VTI1B WDR83 YIPF6
Entrez ID		50855	92359
HPRD ID		06316	16749
Ensembl ID		ENSG00000102981	ENSG00000130545
Uniprot IDs		Q9NPB6	Q9BUF7
PDB IDs		1WMH	5I7Z
Enriched GO Terms of Interacting Partners?
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