PARD6A and PARD6B

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		PARD6A	PARD6B
Description		par-6 family cell polarity regulator alpha	par-6 family cell polarity regulator beta
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Centrosome Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Centriolar Satellite	Nucleus Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Kinase C Binding Protein Binding Transcription Factor Binding GTP-dependent Protein Binding Small GTPase Binding	Protein Kinase C Binding Protein Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Cell-cell Junction Maintenance Positive Regulation Of Protein Secretion Cell Division Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Cellular Localization Bicellular Tight Junction Assembly Positive Regulation Of Protein Localization To Centrosome	Cell-cell Junction Assembly Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Cell Division Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly
Pathways		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Tight junction interactions Asymmetric localization of PCP proteins	Tight junction interactions
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Bipolar disorder ( 21771265)
Interacting Genes		26 interacting genes: APP CDC42 CDH5 CRB3 DVL2 ECT2 GLS MAP2K5 MARK2 MARK4 PARD3 PARD6B PLCB1 PLCB3 PRKCG PRKCH PRKCI PRKCZ PTPN21 RAC1 RHOQ TCP10L3 TGFBR1 WDR83 YWHAH YWHAZ	33 interacting genes: APP ARAP3 BANP CDC42 CDCA4 CEP76 FRMD6 GMCL1 GOLGA2 HSF2BP HTRA1 MAGOHB PALS1 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RASSF3 RHOJ RHOQ SIAH1 TCP10L3 TRIB3 TRIM35 WDR83 YWHAB YWHAH YWHAZ ZSCAN4
Entrez ID		50855	84612
HPRD ID		06316	18703
Ensembl ID		ENSG00000102981	ENSG00000124171
Uniprot IDs		Q9NPB6	Q9BYG5
PDB IDs		1WMH
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?