KDM3A and MRTFA

Data Source:
BioGRID (pull down)

		KDM3A	MRTFA
Description		lysine demethylase 3A	myocardin related transcription factor A
Image		No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytoplasm Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Transcription Coregulator Activity Iron Ion Binding Protein Binding Chromatin DNA Binding Histone Demethylase Activity (H3-K9 Specific) Androgen Receptor Binding Dioxygenase Activity	Transcription Coactivator Activity Actin Binding Actin Monomer Binding Protein Binding Leucine Zipper Domain Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Spermatid Nucleus Elongation Hormone-mediated Signaling Pathway Androgen Receptor Signaling Pathway Histone H3-K9 Demethylation Histone H3-K9 Dimethylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Formaldehyde Biosynthetic Process Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Leukemia Inhibitory Factor Regulation Of Stem Cell Population Maintenance Regulation Of Stem Cell Differentiation	Positive Regulation Of Transcription Via Serum Response Element Binding Actin Cytoskeleton Organization Wound Healing, Spreading Of Cells Positive Regulation Of Transcription By RNA Polymerase II Smooth Muscle Cell Differentiation
Pathways		HDMs demethylate histones NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	SUMOylation of transcription cofactors RHO GTPases Activate Formins
Drugs			Latrunculin B
Diseases
GWAS		Atrial fibrillation ( 29892015) Glomerular filtration rate in chronic kidney disease ( 26420894) Ovarian cancer ( 30557369)
Interacting Genes		6 interacting genes: ETV2 H3C14 MRTFA MRTFB MYOCD RIPK2	10 interacting genes: KDM3A MRTFB MVP MYOCD NCOA3 SMARCA4 SRF SUMO1 TRIM54 UBE2I
Entrez ID		55818	57591
HPRD ID		11054	10445
Ensembl ID		ENSG00000115548	ENSG00000196588
Uniprot IDs		Q9Y4C1	A4FUJ8 E7ER32 Q969V6 W0Z7M9
PDB IDs			2KVU 2KW9
Enriched GO Terms of Interacting Partners?
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