TDP1 and LIG3

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		TDP1	LIG3
Description		tyrosyl-DNA phosphodiesterase 1	DNA ligase 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytoplasm Mitochondrion DNA Ligase III-XRCC1 Complex
	Molecular Function	Double-stranded DNA Binding Single-stranded DNA Binding Exonuclease Activity Protein Binding 3'-tyrosyl-DNA Phosphodiesterase Activity	DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding
	Biological Process	Single Strand Break Repair DNA Repair Double-strand Break Repair Nucleic Acid Phosphodiester Bond Hydrolysis	Double-strand Break Repair Via Homologous Recombination DNA Ligation Lagging Strand Elongation Transcription-coupled Nucleotide-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Cell Cycle V(D)J Recombination Mitochondrial DNA Repair Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways		Nonhomologous End-Joining (NHEJ)	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			Bleomycin
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS			Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 19305408 29874175) TPE interval (resting) ( 32386560)
Interacting Genes		2 interacting genes: LIG3 TOP1	8 interacting genes: APP JTB NEIL1 PARP1 TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		55775	3980
HPRD ID		06226	02966
Ensembl ID		ENSG00000042088	ENSG00000005156
Uniprot IDs		A0A024R6L5 B3KN41 G3V2F4 Q9NUW8	P49916
PDB IDs		1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0 5NW9 5NWA 6DHU 6DIE 6DIH 6DIM 6DJD 6DJE 6DJF 6DJG 6DJH 6DJI 6DJJ 6MJ5 6MYZ 6MZ0 6N0D 6N0N 6N0O 6N0R 6N17 6N19	1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?