TRAFD1 and NGLY1

Data Source:
BioGRID (two hybrid, two hybrid)

		TRAFD1	NGLY1
Description		TRAF-type zinc finger domain containing 1	N-glycanase 1
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GO Annotations	Cellular Component		Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Metal Ion Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Innate Immune Response	Protein Folding Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Glycoprotein Catabolic Process Protein Deglycosylation
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 30718733) Alcohol consumption (max-drinks) ( 29460428) Alcohol dependence symptom count ( 29460428) Aspartate aminotransferase levels ( 30718733) Body mass index ( 26426971 25673413) Coffee consumption ( 29367735) Hemoglobin ( 19862010) Hemoglobin levels ( 32327693) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary biliary cholangitis ( 26394269) Response to alcohol consumption (flushing response) ( 29460428) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 17554300) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: HTT NGLY1 TRAF6 UBC	18 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBQLN1 UBXN2B VCP VMAC
Entrez ID		10906	55768
HPRD ID		10994	10118
Ensembl ID		ENSG00000135148	ENSG00000151092
Uniprot IDs		A0A024RBK4 O14545	Q96IV0
PDB IDs		2D9K	2CCQ 2CM0
Enriched GO Terms of Interacting Partners?
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