INAVA and CYTH2

Data Source:
BioGRID (pull down)

		INAVA	CYTH2
Description		innate immunity activator	cytohesin 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Cytoplasm Cytosol Plasma Membrane Adherens Junction Bicellular Tight Junction Membrane Growth Cone
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Activation Of MAPK Activity Pattern Recognition Receptor Signaling Pathway Cytokine Production Involved In Immune Response Positive Regulation Of Protein Ubiquitination Response To Peptidoglycan Response To Muramyl Dipeptide Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Stress-activated MAPK Cascade Adherens Junction Maintenance Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Intestinal Epithelial Structure Maintenance Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Reactive Oxygen Species Biosynthetic Process	Endocytosis Actin Cytoskeleton Organization Regulation Of ARF Protein Signal Transduction Regulation Of Catalytic Activity
Pathways			Intra-Golgi traffic
Drugs			Inositol 1,3,4,5-Tetrakisphosphate Formic acid 1D-myo-inositol 1,4,5-trisphosphate S,S-(2-Hydroxyethyl)Thiocysteine Brefeldin A
Diseases
GWAS		Celiac disease ( 30572963)	Abstraction and mental flexibility ( 31596458)
Interacting Genes		3 interacting genes: CYTH1 CYTH2 CYTH3	31 interacting genes: ADORA2A ALDOA APC ARF1 ARF6 ARFGAP1 ARL4A ARL4D ARRB1 ARRB2 ATP6V0A1 ATP6V0A2 ATP6V0A4 CCDC120 CNKSR1 CUX1 CYTIP DOCK1 GGA3 GNAQ INAVA IPCEF1 ITGB2 MAPK6 PIK3CA PNPLA2 PRKCA PRKCB PRKCG TCIRG1 TRIM23
Entrez ID		55765	9266
HPRD ID		07712	03925
Ensembl ID		ENSG00000163362	ENSG00000105443
Uniprot IDs		Q3KP66	Q99418
PDB IDs			1PBV 1R8M 1R8Q 1R8S 1S9D 4JMI 4JMO 4JWL 4JXH 4L5M 4Z21
Enriched GO Terms of Interacting Partners?
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